CXCR4 - Wikipedia
WEBCXCR4 is a chemokine receptor that binds to SDF-1, ubiquitin and MIF. It is involved in stem cell homing, HIV infection, implantation, neuronal guidance and WHIM syndrome.
The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue ...
WEBAug 28, 2020 · The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of non-hematopoietic cells.
CXCR4 Gene - GeneCards | CXCR4 Protein | CXCR4 Antibody
WEBAug 5, 2024 · CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome 1 and Macroglobulinemia, Waldenstrom 1. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Nervous system development.
CXCR4 C-X-C motif chemokine receptor 4 [ (human)] - National …
WEB4 days ago · CXCR4 promotes migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway. Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients.
CXCR4: a key receptor in the crosstalk between tumor cells and …
WEBMar 1, 2006 · CXCR4 promotes tumor progression by direct and indirect mechanisms. First, CXCR4 is essential for metastatic spread to organs where CXCL12 is expressed, and thereby allows tumor cells to access cellular niches, such as the marrow, that favor tumor-cell survival and growth.
Involvement of CXCR4 in Normal and Abnormal Development
WEBFeb 20, 2019 · CXC motif chemokine receptor type 4 (CXCR4) is associated with normal and abnormal development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor (SDF), also known as CXC motif ligand (CXCL) 12.
CXCR4 gene - MedlinePlus
WEBThe CXCR4 gene provides instructions for making a receptor protein that spans the outer membrane of cells, specifically white blood cells and cells in the brain and spinal cord (central nervous system). Learn about this gene and related health conditions.
CXCR4: from B-cell development to B cell–mediated diseases
WEBCXCR4 is a G protein–coupled receptor that binds to CXCL12 and regulates leukocyte trafficking. It plays a key role in B-cell maturation, tolerance, and pathogenesis, and is a potential therapeutic target for immunodeficiencies and autoimmune disorders.
CXCR4, the master regulator of neutrophil trafficking in
WEBIn this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease.
CXCR4, the master regulator of neutrophil trafficking in …
WEBMay 7, 2018 · CXCR4 has been shown to be a master regulator of neutrophil retention in the bone marrow and mobilisation during inflammatory responses in mouse at least and unexpectedly also in neutrophil clearance.