CXCR3 - Wikipedia
CXCR3 is a G protein-coupled receptor that binds to CXC chemokines and regulates leukocyte trafficking. It is expressed on activated T lymphocytes and NK cells, and mediates Th1 cell recruitment and polarization in inflammation.
CXCR3 in T cell function - PubMed
Mar 10, 2011 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells. …
The role of CXCR3 and its ligands in cancer - PMC
CXCR3 is present in tumor and immune cells, and its two variants, CXCR3-A and CXCR3-B, have different molecular characteristics and can mediate biological effects with opposite results. Blocking CXCR3-A in tumor cells may be a novel anti-tumor strategy to prevent tumor cell invasion and metastasis.
The duality of CXCR3 in glioblastoma: unveiling autocrine and
Dec 16, 2023 · This review summarizes existing evidence on the oncogenic function of CXCR3 and its ligands CXCL9, CXCL10, and CXCL11, in GBM, and examines the controversies concerning the immunomodulatory ...
Structural insights into the activation and inhibition of CXC
Jan 4, 2024 · By revealing the binding patterns and the pharmacological properties of the four modulators, we present the activation mechanisms of CXCR3 and provide insights for future drug development.
CXCR3 Gene - GeneCards | CXCR3 Protein | CXCR3 Antibody
Oct 1, 2024 · CXCR3 is a protein coding gene that encodes a receptor for C-X-C chemokines involved in leukocyte traffic and inflammation. Learn about its aliases, disorders, pathways, products, variants, and more from GeneCards database.
The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and …
CXCR3 (GPR9/CD183) is an interferon-inducible chemokine receptor expressed on various cell types, but preferentially monocytes, Th1 T cells, CD8 T cells, NKT cells, NK cells, dendritic cells, and some cancer cells (19–21). Homeostatic proliferation of T cells in immune depleted individuals can also lead to an enrichment of CXCR3 + T cells ...
CXCR3 ligands: redundant, collaborative and antagonistic functions
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation, and preferentially remains highly expressed on type-1 helper (Th1)-type CD4(+) T cells, effector CD8(+) T cells and innate-type lymphocytes, such as natural killer (NK) and NKT cells.
The chemokine receptor CXCR3 promotes CD8 - Science
Jan 3, 2024 · The scRNA-seq data show that the high expression of chemokine receptor Cxcr3 (Cxcr3 hi) was predominantly associated with T eff subsets, in contrast with its low-level expression by T CM and T N CD8 + T cell subsets, designated as Cxcr3 low (Fig. 3, A and B).
CXCR3 C-X-C motif chemokine receptor 3 [ (human)] - National …
Oct 10, 2024 · Human chemokine receptor CXCR3 (CXCR3-B) transduces apoptotic but not chemotactic signals in microvascular endothelial cells following exposure to high concentrations of CXCL4. CXCR3 <-> ligand-mediated lymphocyte recruitment is involved in cutaneous lichenoid graft-versus-host disease.