CX3CL1 - Wikipedia
Fractalkine, also known as chemokine (C-X3-C motif) ligand 1, is a protein that in humans is encoded by the CX3CL1 gene.
CX3CL1 Gene - GeneCards | X3CL1 Protein | X3CL1 Antibody
Oct 1, 2024 · CX3CL1 (C-X3-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CX3CL1 include Chorioretinitis and Pityriasis Rosea. Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling.
CX3CL1 Signaling in the Tumor Microenvironment - PubMed
The reported role of CX3CL1 as a key regulator of cytotoxic T cell-mediated immunity is supported by several studies that demonstrate CX3CL1 as an important TIL-recruiting chemokine and a positive prognostic factor in colorectal, breast, and lung cancer.
CX3CL1 C-X3-C motif chemokine ligand 1 [ (human)] - National …
CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma. Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer. T helper cells expressing fractalkine receptor and bearing T follicular helper 1-like cell functions in patients with IgG4-related disease.
CX3CL1 - an overview | ScienceDirect Topics
CX3CL1 is a chemokine expressed by neurons that can exist in both trans-membrane and soluble forms, playing a crucial role in neuron-microglia communication and neuroprotection. AI generated definition based on: Neuroscience, 2020
CX3CL1/CX3CR1 signaling targets for the treatment of ... - PubMed
CX3CL1 is produced in neurons and is a unique chemokine that is initially translated as a transmembrane protein but can be proteolytically processed to generate a soluble chemokine. CX3CL1 has been shown to signal through its sole receptor CX3CR1, which is located on microglial cells within the central nervous system (CNS).
Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 …
Aug 26, 2013 · Studies on animal models have shown that the blockade of the CX3CL1/CX3CR1 pathway ameliorates the severity of atherosclerosis, while genetic epidemiology has confirmed that a genetically-defined...
Regulation and biological functions of the CX3CL1-CX3CR1 axis …
Jan 1, 2021 · The CX3CL1-CX3CR1 axis has several levels of regulation, including cytokine stimulation, hypoxia, activation of transcription factors, posttranscriptional modifications and proteolytic shedding. CX3CL1 is a target for the enzymes ADAM 10 and 17, Cathepsin S and some metalloproteinases, such as MMP-3.
Two forms of CX3CL1 display differential activity and rescue cognitive ...
May 14, 2020 · Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within the brain, a state that plays a major role in aging and neurodegeneration.
Role of CX3CL1 in Diseases | Archivum Immunologiae et Therapiae ...
Apr 20, 2016 · CX3CL1 is a unique chemokine that can exist in a soluble form, as a chemotactic cytokine, or in a membrane-attached form that acts as a binding molecule. Recently, the effects of CX3CL1 on diseases, such as inflammation and cancer, have been supported and confirmed by numerous publications.