CTCF - Wikipedia
WEBTranscriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5][6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V (D)J recombination [7] and regulation of chromatin architecture. [8]
CTCF as a multifunctional protein in genome regulation and …
WEBJun 5, 2015 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator...
CTCF: an architectural protein bridging genome topology and …
WEBMar 11, 2014 · Key Points. CCCTC-binding factor (CTCF) is an architectural protein that can mediate both interchromosomal and intrachromosomal interactions. The functional outcomes of these interactions...
CTCF: the protein, the binding partners, the binding sites and …
WEBJun 6, 2013 · CTCF is a ubiquitously expressed and an essential protein [1], and is, in many ways, an exceptional transcription factor. It was first described as a transcriptional repressor [2], but was also found to act as a transcriptional activator [3, 4].
CTCF Gene - GeneCards | CTCF Protein | CTCF Antibody
WEBAug 5, 2024 · This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins.
CTCF: the protein, the binding partners, the binding sites and …
WEBMay 6, 2013 · Here, we will discuss genome-wide features of CTCF binding events, as well as locus-specific functions of this remarkable transcription factor. Keywords: CTCF; chromatin loops; cohesin; nuclear organization; transcription.
The PTM profiling of CTCF reveals the regulation of 3D ... - Nature
WEBApr 1, 2024 · CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify...
CTCF shapes chromatin structure and gene expression in health …
WEBAug 22, 2022 · CCCTC‐binding factor (CTCF) is a conserved transcriptional regulator composed of 11 central zinc‐finger domains (ZFs) and peripheral, unstructured N‐ and C termini. CTCF binds a relatively long and complex motif which can be present in the DNA in a forward or reverse orientation.
CTCF: An Architectural Protein Bridging Genome Topology and …
WEBA combination of microscopy and chromosome conformation capture (3C)-related approaches 2 revealed that CCCTC-binding factor (CTCF) is in large part responsible for bridging the gap between nuclear organization and gene expression. CTCF is the main insulator protein described in vertebrates.
Distinct properties and functions of CTCF revealed by a rapidly ...
WEBCCCTC-binding factor (CTCF) is a DNA-binding protein with diverse roles in chromatin architecture and gene regulation. The contextual basis for distinct CTCF functions remains largely unknown. As an architectural protein in chromatin, one role of CTCF involves domain organization.
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