Cytokeratin 7 (CK7, K7) - Pathology Outlines
WEBA. Of the above, CK7 is the best screening marker for primary, extramammary Paget disease. Sox10 would be positive in a melanocytic lesion (i.e. melanoma in situ), p63 positive in squamous cell carcinomas or primary adnexal neoplasms and uroplakin is positive in pagetoid urothelial intraepithelial neoplasia (PUIN).
Pathology Outlines - Clear cell
WEBMay 2, 2024 · Comment: Tumor cells show positive immunostaining for PAX8, CAIX and keratin CAM 5.2. CK7 is negative arguing against clear cell papillary renal cell tumor. Kidney, radical nephrectomy: Clear cell renal cell carcinoma, WHO / ISUP grade 3, measuring 2.5 cm in greatest dimension (see comment) Tumor is confined within the …
Pathology Outlines - High grade serous carcinoma
WEBThe tumor cells are positive for CK7 and PAX8 with abnormal (overexpression) of p53 but negative for CK20. Estrogen receptor and progesterone receptor expression is negative. These features are best characterized as high grade serous carcinoma which displays a SET (solid, pseudoendometrioid or transitional) pattern.
Intrahepatic cholangiocarcinoma (small and large duct types)
WEBAug 23, 2021 · Intrahepatic cholangiocarcinoma (iCCA) is a malignant intrahepatic epithelial neoplasm with biliary differentiation, arising in the liver periphery / proximal to the left and right hepatic ducts (WHO 2019) iCCA classification systems (Surg Pathol Clin 2018;11:403, Nat Rev Gastroenterol Hepatol 2020;17:557): Histologic features.
Pathology Outlines - Renal cell carcinoma (RCC)
WEBFeb 16, 2022 · A panel of immunohistochemistry stains show tumor cells to be positive for CD10 and RCC Ma, while being negative for CK7, CK20, PAX8, CD117 and CAIX. While the immunohistochemistry profile is not entirely concordant with a renal primary, especially with negative PAX8 and CAIX, the positivity of both CD10 and RCC Ma would suggest …
Pathology Outlines - Basal cell carcinoma
WEBDec 15, 2020 · Definition / general. Basal cell carcinoma (BCC) arises from the interfollicular or follicular epithelium. Most common malignant tumor type in humans. Local aggressive course. Low disease associated death rate; metastases to lung and bone exceptionally rare.
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WEBApr 10, 2024 · CK7+ (variable), CK20+ (variable), CDX2 (variable), high molecular cytokeratin (variable), beta catenin negative for nuclear staining Müllerian type carcinoma of the bladder and the urethra: Most commonly arise from endometriosis; Clear cell adenocarcinoma: PAX8+, HNF-1B+, AMACR+ Villous adenoma: Rare benign neoplasm …
Invasive breast cancer of no special type (NST)
WEBJun 23, 2022 · IBC NST with < 10% special type should be classified as IBC NST with an option to describe the focal specialized pattern in the report comment. Invasive breast carcinoma with > 90% specialized type patterns should be classified as the special type. When IBC NST contains a component of specialized tumor type that comprises > 10% …
Pathology Outlines - Paget disease
WEBApr 2, 2024 · B. CK7. Given the history of a pruritic lesion of years in duration, along with the microscopic image of mucicarmine positive cells percolating through the epidermis, the diagnosis is most likely extramammary Paget disease, which is strongly CK7 positive.
Pathology Outlines - Invasive urothelial carcinoma
WEBApr 6, 2021 · Urothelial carcinoma is morphologically heterogenous with many variants and subtypes (Surg Pathol Clin 2018;11:713) Invasive urothelial carcinoma involving the lamina propria (T1) is often treated with conservative intravesical therapy and mucosal resection (Ann Diagn Pathol 2007;11:395)