Cytokeratin 19 (CK19, K19) - Pathology Outlines
Definition / general. Molecular weight is 40 kDa (smallest cytokeratin) Often coexpressed with CK7. Present in both simple and complex epithelium. Involved in the organization of myofibers; links contractile apparatus to dystrophin at costameres of …
The use of Cytokeratin 19 (CK19) immunohistochemistry in ... - PubMed
Cytokeratin 19 (CK19) belongs to a family of keratins, which are normally expressed in the lining of the gastroenteropancreatic and hepatobiliary tracts. CK19 immunohistochemistry has been used successfully in thyroid tumors to recognize papillary carcinomas for some time.
The distinct responsiveness of cytokeratin 19-positive ... - Nature
Nov 16, 2021 · Cytokeratin 19-positive (CK19+) hepatocellular carcinoma (HCC) is an aggressive subtype characterized by early recurrence and chemotherapy tolerance. However, there is no specific...
Diagnostic and prognostic impact of cytokeratin 19
Sep 1, 2021 · CK19 upregulation was linked to nodal metastases in neuroendocrine tumors and papillary thyroid carcinomas (p < 0.05 each) and to poor grade in clear cell renal cell carcinoma (p < 0.05). CK19 upregulation was particularly common in squamous cell carcinomas.
Clinical significance of cytokeratin 19 and OCT4 as survival …
Cytokeratin 19 (CK19) is a specific epithelial cytoskeleton marker that is used to detect tumour cells in the peripheral blood, bone marrow, and lymph nodes of cancer patients; it is highly expressed in epithelial tumours such as BC [7].
CK19-positive Hepatocellular Carcinoma is a Characteristic …
Jun 28, 2020 · Cytokeratin 19 (CK19) is well acknowledged as a biliary/progenitor cell marker and a marker of tumor stem cell. CK19-positive HCCs demonstrate aggressive behaviors and poor outcomes which including worse overall survival and early tumor recurrence after hepatectomy and liver transplantation.
Cytokeratin 19 - Libre Pathology
Cytokeratin 19, abbreviated CK19, is a commonly available (low molecular weight) keratin immunostain.
Evaluation of cytokeratin 19 as a prognostic tumoral and metastatic ...
CK19 belongs to the Type I CKs, serves as a useful research tool in prognosis, diagnosis, and management of the tumors. In this paper, we dissect the metastatic potential of CK19, its relation with cancer stem cells and retinal epithelial cells behavior, its application as a tumor marker and its role among 30 cancers such as thyroid, thoracic ...
Diagnostic and prognostic impact of cytokeratin 19 expression …
CK19 downregulation was linked to high grade (p = 0.0017) and loss of estrogen receptor- and progesterone receptor-expression (p < 0.0001 each) in invasive breast carcinoma of no special type. CK19 upregulation was linked to nodal metastases in neuroendocrine tumors and papillary thyroid carcinomas (p < 0.05 each) and to poor grade in clear ...
Cytokeratin 19 immunoreactivity in the diagnosis of papillary …
In our study, we found that diffuse and strong expression of CK19 is characteristic of PTC, both usual type and follicular variant. Although weak CK19 staining is common in MNG and FAs, a negative stain is a good evidence against PTC.
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