CHD1 Gene - GeneCards | CHD1 Protein | CHD1 Antibody
Oct 1, 2024 · CHD1 (Chromodomain Helicase DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with CHD1 include Pilarowski-Bjornsson Syndrome and Stroke, Ischemic. Among its related pathways are ESR-mediated signaling and Signal Transduction.
Chd1 protects genome integrity at promoters to sustain ... - Nature
Aug 11, 2021 · The chromatin remodeler Chd1 mediates hypertranscription in pluripotent cells but its mechanism of action remains poorly understood. Here we report a novel role for Chd1 in protecting genome...
Nucleosome recognition and DNA distortion by the Chd1 ... - Nature
Feb 16, 2022 · Chd1 is named for three characteristic domains: a pair of chromodomains, a helicase-like ATPase motor and a DNA-binding domain (DBD) 19. Using its ATPase motor, Chd1 repositions nucleosomes by...
Nucleosome–Chd1 structure and implications for chromatin …
Oct 11, 2017 · Chd1 contains the DNA-binding domains SANT and SLIDE, a bilobal motor domain that hydrolyses ATP, and a regulatory double chromodomain. Here we report the cryo-electron microscopy structure of...
Human CHD1 is required for early DNA-damage signaling and is uniquely ...
May 4, 2018 · CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defect in early double-strand break (DSB) repair via h ….
CHD1 chromodomain helicase DNA binding protein 1 [ (human)]
CHD1 is the 5q21 tumor suppressor gene in prostate cancer; findings suggest that CHD1 deletion may underlie cell invasiveness in a subset of prostate cancers, and indicate a possible novel role of altered chromatin remodeling in prostate tumorigenesis
CHD1 - an overview | ScienceDirect Topics
The CHD1 gene encodes the chromo-domain helicase DNA-binding protein 1, which is involved in several biological processes, including chromatin remodeling, recruitment of HRR proteins to double-strand DNA breaks and AR-dependent transcriptional control.
Diversity roles of CHD1L in normal cell function and tumorigenesis
CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcriptional regulation through its bindings to DNA. By regulating kinds of complex networks, CHD1L has been identified as a potent anti-apoptotic and pro-proliferative factor.
CHD1, a multifaceted epigenetic remodeler in prostate cancer
Jan 26, 2023 · The chromodomain helicase DNA-binding (CHD) family of remodelers plays crucial roles in embryonic development, hematopoiesis, and neurogenesis. As the founding member, CHD1 is capable of assembling nucleosomes, remodeling chromatin structure, and regulating gene transcription.
Chromatin Regulator, CHD1, Remodels the Immunosuppressive …
We previously identified chromodomain-helicase-DNA-binding protein 1 (CHD1) as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive in vivo genetic evidence for, and mechanistic understanding of, the essential role of CHD1 in PTEN-deficient prostate cancer.
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