Cyclin-dependent kinase 8 - Wikipedia
Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. [5][6] Function. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate with the mediator complex and regulate transcription by several mechanisms.
CDK8 Gene - GeneCards | CDK8 Protein | CDK8 Antibody
Oct 1, 2024 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities and Ebstein Malformation Of The Tricuspid Valve.
CDK8 is a positive regulator of transcriptional elongation ...
Jan 24, 2010 · Cyclin-dependent kinase 8 (CDK8), the kinase found in some variants of Mediator, has been characterized mostly as a transcriptional repressor. Recently, CDK8 was demonstrated to be a potent...
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase ...
Jan 14, 2019 · This has led to intense efforts to understand how CDK8/19 regulate diverse biological outputs and develop Mediator kinase inhibitors that can be exploited therapeutically. Herein, we review both context and function of the Mediator kinases at a …
A kinase-independent role for CDK8 in BCR-ABL1 - Nature
Oct 18, 2019 · Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL.
Structure and noncanonical Cdk8 activation mechanism within ...
Jan 15, 2021 · The Cdk8 kinase module (CKM) in Mediator, comprising Med13, Med12, CycC, and Cdk8, regulates RNA polymerase II transcription through kinase-dependent and -independent functions. Numerous pathogenic mutations causative for neurodevelopmental disorders and cancer congregate in CKM subunits.
CDK8 - PMC - National Center for Biotechnology Information
CDK8 belongs to a group of cyclin-dependent kinases involved in transcriptional regulation from yeast to mammals. CDK8 associates with the Mediator complex, but functions outside of Mediator are also likely.
The Cdk8 kinase module regulates interaction of the mediator ...
Nov 10, 2020 · The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex mediator, which regulates gene transcription by RNA polymerase II. The CKM has both negative and positive functions in gene transcription that remain poorly understood at the mechanistic level.
CDK8-Novel Therapeutic Opportunities - PMC
Jun 19, 2019 · Recent evidence supports the idea that cyclin-dependent kinase 8 (CDK8) may represent a potential drug target for breast and prostate cancer, although no CDK8 inhibitors have entered the clinics.