CDK7 Gene - GeneCards | CDK7 Protein | CDK7 Antibody
WEBAug 5, 2024 · CDK7 (Cyclin Dependent Kinase 7) is a Protein Coding gene. Diseases associated with CDK7 include Xeroderma Pigmentosum, Variant Type and Breast Cancer. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Initiation And Promoter Clearance.
Cdk7: a kinase at the core of transcription and in the ... - PubMed
WEBCdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK-activating kinase (CAK) for at least one other essential CDK involved in transcription.
Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel …
WEBFeb 14, 2024 · Cyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to its dual role in transcription and cell cycle...
The Mediator captures CDK7, an attractive transcriptional target in ...
WEBSep 13, 2021 · Recent efforts to develop small molecule inhibitors that target cyclin-dependent kinase 7 (CDK7) have suggested that CDK7 may play a critical role in mediating the transcription of key cancer dependence genes.
CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?
WEBMar 9, 2020 · Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed in various types of cancer, its downregulation leads to …
CDK7 inhibitors as anticancer drugs - PubMed
WEBCyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-activating complex (CAK), which directs progression through the cell cycle via T-loop phosphorylation of cell cycle CDKs. CAK is also a component of the …
Inhibition of the transcriptional kinase CDK7 overcomes therapeutic ...
WEBAug 28, 2019 · CDK7 promotes cell cycle progression through inhibition of transcription, rather than via direct phosphorylation of classical CDK targets. The transcriptional kinase activity of CDK7 is regulated...
Cyclin-dependent kinase 7 inhibitors in cancer therapy
WEBCyclin-dependent kinase 7 (CDK7) plays crucial roles in the regulation of cell cycle and transcription that are tightly associated with cancer development and metastasis.
CDK inhibitors in cancer therapy, an overview of recent …
WEBMay 15, 2021 · CDK7 inhibitors. CDK7 has dual functions of cell cycle controlling and transcriptional regulation, which make CDK7 a potential target for cancer therapy. Several CDK7 specific inhibitors have been shown significant anti-tumor activity, including non-covalent inhibitors BS-181, ICEC0942, LDC4297, QS1189 and covalent inhibitors THZ1, …
Cdk7: a kinase at the core of transcription and in the crosshairs of ...
WEBDec 6, 2018 · Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK-activating kinase (CAK) for at least one other essential CDK involved in transcription.
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