Inhibition of the CDK2 and Cyclin A complex leads to autophagic ...
WEBMay 20, 2022 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against CDK2 are ATP...
Targeting CDK2 in cancer: challenges and opportunities for therapy
WEBCDK2 and its regulatory subunits are deregulated in many human cancers and there is emerging evidence suggesting CDK2 inhibition elicits antitumor activity in a subset of tumors with defined genetic features. Previous CDK2 inhibitors were nonspecific and limited by off-target effects.
CDK2 Gene - GeneCards | CDK2 Protein | CDK2 Antibody
WEBAug 5, 2024 · CDK2 (Cyclin Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include Breast Cancer and Gastric Fundus Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Defective binding of RB1 mutants to E2F1, (E2F2, E2F3).
Targeting CDK2 in cancer: challenges and opportunities for therapy
WEBFeb 1, 2020 · CDK2 has key roles in cell cycle, DNA replication and DNA damage. •. Multiple biomarkers can indicate increased CDK2 activity. •. Some cancers have particular susceptibility to CDK2 inhibition. •. The development …
Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An …
WEBDec 13, 2018 · Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types.
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases …
WEBMar 13, 2021 · In dividing cells, cyclin-dependent kinase 2 (CDK2) is a major cell cycle component that controls the G1/S and S/G2 transitions. CDK2/CycE must phosphorylate Rb to induce S phase entry ( mouse embryonic fibroblasts–MEFs ) [ 22 ].
Cyclin-Dependent Kinase 2 - an overview | ScienceDirect Topics
WEBCyclin-dependent kinase 2 (CDK2) is a protein kinase that is essential for controlling cell division and the cell cycle. CDK2 dysregulation has been linked to several cancer forms, leading to it being an ideal target for therapeutic development.
Cyclin-dependent kinase 2 (CDK2) - ScienceDirect
WEBJan 1, 2024 · S and M phases of the mammalian cell cycle are urged by cyclin-dependent kinase 2 (CDK2). CDK2 is a metalloenzyme possessing Mg + ion in its active site. Although CDK2 activity is mainly redundant for regular development, it is directly coupled with tumor progression in various malignancies.
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic ...
WEBNov 24, 2021 · Cyclin E/CDK2 complex mostly controls cell cycle progression and DNA replication through phosphorylation of specific substrates. Oncogenic activation of Cyclin E/CDK2 complex impairs normal DNA replication, …
A key role for CDK2 - Nature Reviews Cancer
WEBTwo papers reveal that cyclin-dependent kinase 2 (CDK2) both suppresses the induction of senescence by MYC and phosphorylates MYC to bypass Ras-induced senescence. Expression of MYC can...
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