CDC42 Gene - GeneCards | CDC42 Protein | CDC42 Antibody
Oct 1, 2024 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and GPCR Pathway.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung ...
Sep 4, 2017 · Cell division cycle 42 (CDC42) plays important roles in polarity establishment and maintenance as well as cell cycle progression and cell division.
Cdc42, a Rho GTPase and regulator of actin-based ... - Cytoskeleton
Cdc42 localizes to membranes via a post-translational C-terminal geranylgeranyl lipid modification; however, it can be found as a soluble complex association with RhoGDI (Rho GDP-dissociation inhibitor), another means of regulating Cdc42’s activation.
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes …
Jan 6, 2019 · Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking.
Regulating Cdc42 and Its Signaling Pathways in Cancer: Small …
Mar 29, 2018 · In this review, we analyze the newly recognized regulation mechanisms for Cdc42 and Cdc42-related signal pathways, and particularly new treatments using small molecules and miRNAs to inhibit the abnormal overexpression of Cdc42 that may slow down the metastasis process, improve cancer therapy and lead to novel strategies for development of ...
A Cdc42-mediated supracellular network drives polarized forces …
Apr 21, 2020 · Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.
Cdc42 regulates cell polarization and contractile actomyosin rings ...
Jul 16, 2020 · We herein investigated the effects of the Cdc42 inhibitor, CASIN, on cytokinesis and enucleation in colony-forming units-erythroid (CFU-Es) and mature erythroblasts (day 10).
The Small GTPase Cdc42 Is a Major Regulator of Neutrophil …
Jun 11, 2020 · Cdc42 is a major regulator of ROS formation, degranulation as well as activation of neutrophils in a stimulus dependent manner. We reported that Cdc42 seems to be a positive regulator of LPS induced effector mechanisms while it appears to be a negative regulator of GPCR-triggered neutrophil functions.
Activation of Endogenous Cdc42 Visualized in Living Cells | Science …
Sep 10, 2004 · The biosensor revealed Cdc42 activation in the trans-Golgi compartment, microtubule-dependent activation at the cell periphery but not in filopodia, and tightly coordinated kinetics of cell extension, retraction, and Cdc42 activation.
The role of cell division control protein 42 in tumor and non-tumor ...
Jan 1, 2022 · Cdc42 is one of the most important members of the Rho-GTP family and it is found first in fission yeast. It plays a crucial role in regulating the cell cycle, controlling gene transcription, regulating the cytoskeleton, cell movement, and polarization.
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