CD81 - Wikipedia
CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. [5] [6] It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan-28).
CD81 Gene - GeneCards | CD81 Protein | CD81 Antibody
Oct 1, 2024 · CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency . Among its related pathways are Complement cascade and Innate Immune System .
CD81 and Hepatitis C Virus (HCV) Infection - PMC - National …
Feb 6, 2014 · Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells and for which the initiation of infection occurs through a complex multistep process involving a series of specific cellular entry factors.
Structural insights into hepatitis C virus receptor binding ... - Nature
Sep 15, 2021 · CD81 is ubiquitously expressed in a variety of cell lines, indicating that it has a role secondary to hepatocyte-specific receptor binding. CD81 translocates with the virion to tight junctions...
CD81 (TAPA-1): A MOLECULE INVOLVED IN SIGNAL …
CD81 (TAPA-1) is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It has been cloned independently several times for different functional effects and is reported to influence adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells.
CD81 as target for B cell lymphomas - PMC - National Center for ...
Jul 1, 2019 · The functions of CD81 are multifaceted, including roles in immune synapse formation, adhesion, migration, receptor clustering, and signaling. In B cells, CD81 forms a complex with CD19 and CD21 and thereby lowers the threshold for B cell receptor activation.
CD81 - an overview | ScienceDirect Topics
CD81 (encoded by the CD81 gene) deficiency is a human autosomal recessive disorder also resulting in hypogammaglobulinemia. CD81 is a tetraspanin molecule expressed on immune cells, hepatocytes, and most stromal and epithelial cells, unlike CD19 and CD21 which are mostly expressed on B cells.
CD81 Protein is Expressed at High Levels in Normal Germinal …
CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes and enables hepatitis C virus infection of human cells.
CD81 - an overview | ScienceDirect Topics
CD81, a widely expressed tetraspanin molecule, is a candidate cellular receptor for hepatitis C virus (HCV). Recent studies show that CD81 has high affinity for the HCV E2 envelope glycoprotein.
Pax5 mediates the transcriptional activation of the CD81 gene
Nov 25, 2021 · CD81 is an integral membrane protein of the tetraspanin family and forms complexes with a variety of other cell surface membrane proteins. CD81 is involved in cell migration and B cell...
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