CD73：肿瘤免疫治疗的靶点新星 - 知乎 - 知乎专栏
CD73的结构. CD73又称胞外-5’-核苷酸酶(Ecto-5’-Nucleotidase)，是由NT5E基因编码的一种细胞表面，是催化AMP形成胞外腺苷的主要酶[1]。人CD73的基因位于染色体6q14-921。CD73的进化相当保守，人CD73的cDNA序列与鼠的cDNA序列有86%的同源性[2]。
NT5E - Wikipedia
NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine .
CD73: an emerging checkpoint for cancer immunotherapy - PMC
Jun 21, 2019 · CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes tumor progression by suppressing antitumor immune response and promoting angiogenesis. The inhibition of CD73, in combination with immune checkpoint blockade, targeted therapy or conventional therapy, improves antitumor effects in numerous preclinical mouse ...
CD73: an emerging checkpoint for cancer immunotherapy
CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes tumor progression by suppressing antitumor immune response and promoting angiogenesis. The inhibition of CD73, in combination with immune checkpoint blockade, targeted therapy or conventional therapy, improves antit ….
cd73 不仅通过酶活性产生的腺苷参与到正常的生理活动，其本身也具有一定的生物学功能。 CD73 可以结合细胞外基质成分，如纤连蛋白和层粘连蛋白，还与淋巴细胞、血管内皮细胞及树突状细胞的粘
CD73-mediated adenosine production by CD8 T cell-derived
Oct 8, 2021 · Here we report that human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles upon activation.
CD73 on cancer-associated fibroblasts enhanced by the A2B …
Jan 24, 2020 · Here, we demonstrate that cancer-associated fibroblasts (CAFs) constitute the prominent CD73hipopulation in human colorectal cancers (CRCs) and two CD73−murine tumor models, including a modified...
CD73, a Promising Therapeutic Target of ... - Wiley Online Library
Dec 23, 2022 · CD73, a cell surface-bound nucleotidase, facilitates extracellular adenosine formation by hydrolyzing 5′-AMP to adenosine. Several studies have shown that CD73 plays an essential role in immune escape, cell proliferation and tumor angiogenesis, making it an attractive target for cancer therapies.
CD73 promotes tumor metastasis by modulating RICS/RhoA
Mar 23, 2020 · Tumor microenvironment plays vital roles in shaping cancer diversity, and CD73 (ecto-5′-nucleotidase; NT5E) is an emerging immune checkpoint in modulating cancer progression via conversion of ...
Targeting CD73 to augment cancer immunotherapy - ScienceDirect
Aug 1, 2020 · CD73 (ecto-5′-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal …
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