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  1. Nature
    https://www.nature.com/articles/s41420-023-01396-z

    Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic ...

    • The mechanism of nonalcoholic fatty liver susceptibility to ischemia/reperfusion (IR) injury has not been fully clarified. Caspase 6 is a critical regulator in innate immunity and host defense. We aimed to charact… See more

    Introduction

    Improving the utilization rate of marginal donor liver (e.g., from donors with fatty liver) is an … See more

    Nature
    Results

    Caspase 6 expression is positively associated with hepatic IR injury in fatty livers
    To verify the severity of the effect of IR on fatty liver, li… See more

    Nature
    Discussion

    To the best of our knowledge, this study reveals that macrophage Caspase 6 can activate NR4A1/SOX9 signaling to regulate S100A9 transcription in response to IR-stimulated f… See more

    Nature
    Methods

    Patients and clinical samples
    This study was approved by the Academic Committee of Tianjin Medical University General Hospital (Tianjin, China). Human samples w… See more

    Nature
    Data availability

    The mRNA expression profile data are available in the Figshare databases (Digital Object Identifier: 10.6084/m9.figshare.21981866). Other datasets us… See more

    Nature
    Funding

    This work was supported by the National Natural Science Foundation of China, Grant/Award Number: 81700569, 81700659; Natural Science Foundation of Tianjin, Gra… See more

    Nature
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    Table of Contents
    Introduction
    Results
    Discussion
    Methods
    Data availability
    Funding
     
  1. Studies of CD68 SOX9
    National Center for Biotechnology Information
    Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver
    Improving the utilization rate of marginal donor liver (e.g., from donors with fatty liver) is an important strategy to overcome the clinical problem of donor shortage [1, 2]. Compared with normal liver, steatotic donor liver is more sensitive to ischemia /reperfusion (IR) injury, and the risk of ea...
    Author: Mingwei Shen…
    Published: 2023
    Publication: Cell Deat…
    ScienceDirect
    Sox9 is increased in arterial plaque and stenosis, associated with synthetic phenotype of vascular smooth muscle cells and causes alterations in extracellular matrix and calcification
    Vascular smooth muscle cells (VSMC) exhibit a dual role in progression and maintenance of arteriosclerosis. They are fundamental for plaque stability but also can drive plaque progression. During pathogenic vascular remodeling, VSMC transdifferentiate into a phenotype with enhanced proliferation and...
    Published: 2018/08/01
    Cited By: 0
    Keywords: ApoE−/− Ap…
    PubMed
    SOX9 Immunohistochemistry in the Distinction of Angiomatoid Fibrous Histiocytoma From Histologic Mimics: Diagnostic Utility and Pitfalls
    Angiomatoid fibrous histiocytoma (AFH) can be diagnostically difficult because of its varied histologic appearance and potential to occur at unusual sites. The identification of recurrent rearrangements (EWSR1-CREB1, EWSR1-ATF1, and FUS-ATF1) is a helpful diagnostic tool. Additional immunohistochemi...
    Author: Lara Berklite
    Published: 2020/9
    Keywords: National In…
    National Center for Biotechnology Information
    Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice
    Hepatic repair is directed chiefly by the proliferation of resident mature epithelial cells. Further if predominant injury is to cholangiocytes, the hepatocytes can transdifferentiate to cholangiocytes to assist in the repair and vice versa as shown by various fate-tracing studies. However, the mole...
    Author: Hirohisa Okab…
    Published: 2016/11
    DOI: 10.1002/hep.28774
  2. AHA/ASA Journals
    https://www.ahajournals.org/doi/10.1161/CI…

    Sox9 Accelerates Vascular Aging by Regulating …

    Jan 5, 2024 · Sox9 (SRY-box transcription factor 9) expression in vascular smooth muscle cells (VSMCs) correlates with increased cellular senescence and decreased expression of α-smooth muscle actin (α-SMA). A, Sox9, α-SMA, …

  3. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC9677683

    How vascular smooth muscle cell phenotype switching contributes …

  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043527

    Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic …

  5. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0925443918301790

    Sox9 is increased in arterial plaque and stenosis, associated with ...

  6. Nature
    https://www.nature.com/articles/s42003-02…

    Macrophages regulate vascular smooth muscle cell ...

    Dec 1, 2022 · Culturing of VSMCs with RAW264.7 medium (RM) resulted in the continuously significant downregulation of smooth muscle cell marker α-SMA and upregulation of macrophage marker CD68 at 12 h and ...

  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31567275

    SOX9 Immunohistochemistry in the Distinction of Angiomatoid …

  8. nature.com
    https://www.nature.com/articles/s44161-023-00412-w

    Cholesterol lowering depletes atherosclerotic lesions of ... - Nature

  9. ahajournals.org
    https://www.ahajournals.org/doi/pdf/10.1161/JAHA...
    [PDF]

    Phenotypic Switching of Vascular Smooth Muscle Cells in …

  10. Cell Press
    https://www.cell.com/molecular-therapy-family/...
    [PDF]

    CRISPR-mediated Sox9 activation and RelA inhibition enhance …

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