2 days ago · The TCR CD3 complex is essential for T-cell development within the thymus, guiding immature thymocytes through selection processes that determine their functional fate. In the early thymic progenitor stage, CD3 is expressed in complex with the pre-TCR, a temporary receptor composed of a TCR β chain paired with a surrogate pre-Tα chain. ...

The T cell receptor (TCR)–CD3 complex represents on of the most intricate membrane receptor structures since it is built from six distinct chains. This complexity led to a number of different proposals for the arrangement of the receptor subunits, ...

We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR–CD3 complex, for dynamically-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of CD3 subunits.

Aug 28, 2019 · In this study, we report a cryo-electron microscopy (cryo-EM) structure of a human TCR–CD3 complex in its unliganded state at 3.7 Å resolution. The structure reveals the mechanisms that underlie...

How antigen ligation by the TCR triggers CD3 activation and what structural role the CD3 extracellular domains (ECDs) play in the assembled TCR–CD3 complex remain unclear. Here, we use two complementary structural approaches to gain insight into the overall organization of the TCR–CD3 complex.

Apr 24, 2024 · These findings reveal organizing principles of the γδ TCR–CD3 complex, providing insights into the unique properties of γδ TCR and facilitating immunotherapeutic interventions.

Jun 7, 2024 · CD3 is a protein complex found on the surface of T cells, a type of white blood cell that is central to the immune response. The CD3 complex is composed of several subunits: CD3γ, CD3δ, CD3ε, and CD3ζ. These subunits work together to form a receptor complex that is crucial for T cell activation.

Jan 15, 2025 · The CD3 complex is an integral part of the T-cell receptor (TCR) complex, playing a role in T-cell activation and signal transduction. This multi-subunit structure is composed of several invariant chains, specifically CD3γ, CD3δ, CD3ε, and CD3ζ, which are non-covalently associated with the TCR.

Dec 27, 2002 · The T cell receptor-CD3 complex (TCR-CD3) serves a critical role in the differentiation, survival, and function of T cells, and receptor triggering elicits a complex set of biological responses that serve to protect the organism from infectious agents.

The CD3 complex is composed of four polypeptide chains (CD3γ, CD3δ, CD3ε, and CD3ζ), which are critical for TCR signaling. Upon antigen recognition by the TCR, the CD3 complex undergoes conformational changes that initiate intracellular signaling pathways necessary for T …