KIT (gene) - Wikipedia
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). [5] Multiple transcript variants encoding …
CD117 - an overview | ScienceDirect Topics
CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast cell disorders and identification of myeloblasts in acute leukemias.
KIT (CD117): a review on expression in normal and neoplastic …
CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.
KIT Gene - GeneCards | KIT Protein | KIT Antibody
Oct 2, 2024 · Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
CD117 - an overview | ScienceDirect Topics
The KIT protein or CD117 is a transmembrane protein for a tyrosine kinase receptor encoded by the proto-oncogene c-kit, which, when bound to its ligand stem cell factor (SCF), is essential to the development, proliferation, and maturation of several cell types, including germ cells.
Selective hematopoietic stem cell ablation using CD117 ... - Nature
Feb 6, 2019 · Here we show that a single dose of a CD117-antibody-drug-conjugate (CD117-ADC) to saporin leads to > 99% depletion of host HSCs, enabling rapid and efficient donor hematopoietic cell...
CD117/c-kit in Cancer Stem Cell-Mediated Progression and …
Mar 8, 2018 · The CD117 gene, officially known as “KIT proto-oncogene receptor tyrosine kinase” (GenBank ID: 3815), is also more commonly known as c-kit, kit, or stem cell factor receptor. CD117 was first identified as the cellular homolog of the …
CD117 Expression Is Associated with Cytogenetic and Molecular …
Nov 13, 2019 · The CD117 (c-KIT) receptor tyrosine kinase is expressed on the cell surface of hematopoietic stem cells and its signaling is important in cell survival, proliferation and differentiation. CD117 is expressed in a majority of AML cases.
KIT (CD117): A Review on Expression in Normal and Neoplastic ... - LWW
CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.
Since 1998, when activating mutations in the receptor tyrosine kinase c-kit were first identified in GISTs [1] and im-munohistochemical detection of the protein prod-uct KIT (CD117) was recognized to be a virtually specific diagnostic marker for GISTs among mes-enchymal tumors of the gastrointestinal tract [2], out of the formerly nebulous categ...