Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance.

2 days ago · Explore the essential role of CCR7 in T cell migration, immune organization, and subset function, highlighting its impact on adaptive immunity and tissue dynamics.

Growing evidence suggests that cell trafficking orchestrated by the C-C chemokine receptor 7 (CCR7) plays a critical role in the pathophysiology of several leukemias and lymphomas.

Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.

Aug 17, 2017 · Our study indicates that CCR7 homodimerization critically regulates CCR7 ligand-dependent cell migration and intracellular signaling in multiple cell types. Recruitment of lymphocytes from the...

Sep 1, 2023 · By combining experimental data with theory on leukocyte chemotaxis guided by the G protein–coupled receptor (GPCR) CCR7, we demonstrate that in addition to its role as the sensory receptor that steers migration, CCR7 also acts as a generator and a modulator of chemotactic gradients.

In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA).

Aug 22, 2019 · Here, we present the crystal structure of human CCR7 fused to the protein Sialidase NanA by using data up to 2.1 Å resolution. The structure shows the ligand Cmp2105 bound to an intracellular allosteric binding pocket.

May 1, 2023 · Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells and peripheral immune cells, and plays an important role in regulating behavior in homeostasis and neuroinflammation in disease.

Chemokine receptors promote chemotaxis of cells and tissue organization. Since under homeostatic conditions, CCR7 promotes migration of immune cells to lymph nodes, questions immediately arose regarding the ability of CCR7 to direct migration of …