Jul 22, 2020 · The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor microenvironment through immune cell control. The present article reviewed the role of the CCL20-CCR6 axis in cancer progression and its potential as a therapeutic target.

Jun 15, 2020 · Here, we present a 3.3-Å cryo-electron microscopy structure of the human chemokine receptor CCR6 bound to its endogenous ligand CCL20 and an engineered Go. CCL20 binds in a shallow...

In our review, we aim to introduce the wide array of potential CCR6–CCL20 inhibitors with an emphasis on attendant immune-modulator capacity that have been tested in the research field to date and are immensely promising compounds as forerunners of future curatives.

CCL20 is the only known high-affinity ligand that binds to CCR6 and drives CCR6 + cells' migration in tissues. CCL20 is mainly produced by epithelial cells, and its expression is increased by several folds under inflammatory conditions.

CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins.

Feb 22, 2025 · This review discusses the interaction between the CCL20–CCR6 axis and the tumor microenvironment and how these interactions promote tumor progression. Also, an outline of studies utilizing CCL20 in combination with other standard cancer treatments has been shed.

Dec 27, 2024 · In this paper, we demonstrate the comprehensive involvement of the CCL20-CCR6 axis in immune mechanism responses and elucidate the efficacy of anti-CCL20 and anti-CCR6 treatments in alleviating disease progression to a certain extent.

Oct 1, 2003 · CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3α (MIP-3α) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared …

May 27, 2014 · In this study, we aimed to determine the role of CCL20-CCR6 interactions in spontaneous intestinal tumorigenesis. CCR6-deficient mice were crossed with mice heterozygous for a mutation in the adenomatous polyposis coli (APC) gene (APC MIN/+ mice) to generate APC MIN/+ mice with CCR6 knocked out (CCR6KO-APC MIN/+ mice).

Nov 4, 2024 · We found that CCR6–CCL20 activity in tumor-infiltrating Tregs is associated with greater glycolytic activity and ablation of Ccr6 reduced glycolysis and lactic acid production while increasing compensatory glutamine metabolism.