The CCL20-CCR6 Axis in Cancer Progression - PubMed
Jul 22, 2020 · The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor …
Structural basis for chemokine receptor CCR6 activation by …
Jun 15, 2020 · Here, we present a 3.3-Å cryo-electron microscopy structure of the human chemokine receptor CCR6 bound to its endogenous ligand CCL20 and an engineered Go. …
Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic …
In our review, we aim to introduce the wide array of potential CCR6–CCL20 inhibitors with an emphasis on attendant immune-modulator capacity that have been tested in the research field …
CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
CCL20 is the only known high-affinity ligand that binds to CCR6 and drives CCR6 + cells' migration in tissues. CCL20 is mainly produced by epithelial cells, and its expression is …
The CC chemokine CCL20 and its receptor CCR6 - PubMed
CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to …
CCL20 in the tumor microenvironment: implications for cancer ...
Feb 22, 2025 · This review discusses the interaction between the CCL20–CCR6 axis and the tumor microenvironment and how these interactions promote tumor progression. Also, an …
Progress of CCL20-CCR6 in the airways: a promising new …
Dec 27, 2024 · In this paper, we demonstrate the comprehensive involvement of the CCL20-CCR6 axis in immune mechanism responses and elucidate the efficacy of anti-CCL20 and anti …
The CC chemokine CCL20 and its receptor CCR6 - ScienceDirect
Oct 1, 2003 · CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3α (MIP-3α) or Exodus-1, is the only chemokine known to …
CCR6, the Sole Receptor for the Chemokine CCL20, Promotes …
May 27, 2014 · In this study, we aimed to determine the role of CCL20-CCR6 interactions in spontaneous intestinal tumorigenesis. CCR6-deficient mice were crossed with mice …
The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and ...
Nov 4, 2024 · We found that CCR6–CCL20 activity in tumor-infiltrating Tregs is associated with greater glycolytic activity and ablation of Ccr6 reduced glycolysis and lactic acid production …