CARM1 - Wikipedia
CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene …
CARM1/PRMT4: Making Its Mark beyond Its Function as a ... - PubMed
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins. …
哈佛医学院Kai W. Wucherpfennig团队发现肿瘤免疫新靶点CARM1 …
哈佛医学院Kai W. Wucherpfennig团队在著名期刊Cancer Discovery（IF:38.272）上发表论文：CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor …
CARM1 Gene - GeneCards | CARM1 Protein | CARM1 Antibody
Oct 1, 2024 · CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with CARM1 include Encephalopathy, Neonatal Severe, Due To …
Global mapping of CARM1 substrates defines enzyme specificity and ...
May 24, 2017 · PRMT4 or coactivator-associated arginine methyltransferase 1 (CARM1) is a propitious target for cancer therapy; however, few CARM1 substrates are known, and its …
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by …
A number of cancer drugs activate innate immune pathways in tumor cells but unfortunately also compromise antitumor immune function. We discovered that inhibition of CARM1, an …
CARM1 arginine methyltransferase as a therapeutic target for cancer
May 30, 2023 · Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …
Systematic pan-cancer landscape identifies CARM1 as a potential ...
Jan 16, 2022 · CARM1 has been well known as a transcriptional coactivator, it has also been found to be crucial in regulation of metabolism, autophagy, RNA regulation and early …
Identification of a CARM1 Inhibitor with Potent - Nature
Dec 21, 2017 · We describe the identification and characterization of, to our knowledge, the first potent and selective inhibitor of CARM1 that exhibits anti-proliferative effects both in vitro and …
Tyrosine phosphorylation of CARM1 promotes its enzymatic
Apr 22, 2024 · To determine whether CARM1 is a direct substrate of JAK2, and identify potential CARM1 tyrosine phosphorylation sites, we performed cell-free in vitro kinase assays using …