Dentate gyrus circuits for encoding, retrieval and ... - Nature
WEBFeb 10, 2020 · Dentate gyrus (DG) granule cells (GCs) send mossy-fibre (MF) axons to the CA3. CA3 pyramidal cells send Schaffer-collateral (SC) projections to the CA1, which then projects back to the...
Hippocampus proper - Wikipedia
WEBThe hippocampus proper refers to the actual structure of the hippocampus which is made up of four regions or subfields. The subfields CA1, CA2, CA3, and CA4 use the initials of cornu Ammonis, an earlier name of the hippocampus.
DG–CA3 circuitry mediates hippocampal representations of …
WEBJun 15, 2020 · Here we show that hippocampal subregions CA1 and CA3 represent latent information through changes in firing rate during unconstrained 2D navigation in a novel behavioral paradigm in the absence...
The CA3 region of the hippocampus: how is it? What is it for?
WEBFeb 5, 2015 · The CA3 region has attracted major attention in recent years for its specific role in memory processes, susceptibility to seizures and neuro-degeneration. Internal connectivity in the CA3 subfield is more rich than in other hippocampal regions.
Dentate gyrus circuits for encoding, retrieval and discrimination …
WEBMar 1, 2020 · The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG lesions impair many, but not all hippocampus-dependent mnemonic functions, indicating that the rest of the hippocampus (CA1-CA3) can operate autonomously under certain conditions.
Sharpening the blades of the dentate gyrus: how ... - The EMBO …
WEBSep 25, 2023 · In spite of its highly complex afferent, efferent, and internal connectivity (Hainmueller & Bartos, 2020), the hippocampus is traditionally depicted as having a relatively simple trisynaptic internal circuit (DG – CA3 – CA1), with entorhinal cortex as its major input (Fig 2A).
Differential roles for hippocampal areas CA1 and CA3 in the …
WEBOct 8, 2007 · Within the hippocampus, recent studies have suggested important differences in the function of areas CA1 and CA3 (the principal pyramidal cell fields in the hippocampus) in spatial and contextual memory (Lee et al. 2004; Leutgeb et al. 2005).
Operation and plasticity of hippocampal CA3 circuits ... - Nature
WEBMar 2, 2017 · The CA3 region of the hippocampus is important for rapid encoding of memory. Computational theories have proposed specific roles in hippocampal function and memory for the sparse inputs from the...
Function of local circuits in the hippocampal dentate gyrus-CA3 …
WEBMar 1, 2019 · DG-CA3 network analysis during sleep as well as waking period also provided insights into the principle operations of DG-CA3 local circuits. In this article, I review the function of the neuronal circuits in the DG-CA3 system, …
The hippocampus: Current Biology - Cell Press
WEBDec 7, 2015 · The entorhinal cortex provides the major cortical input to the hippocampus, with its strongest projections via the perforant path to the dentate gyrus (DG) region (Synapse 1). The DG projects to the CA3 region via the mossy fiber pathway (Synapse 2). CA3 projects to the CA1 region via the Schaffer Collateral pathway (Synapse 3).
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