The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

Aug 30, 2021 · C-terminus is one of the terminal groups of two ends of the peptide chain. The end of the polypeptide with a free Carboxyl group (-COOH) is known as C-terminus.

Mar 21, 2025 · Explore the functions of the C terminus in proteins, including its role in stability, modifications, signaling, and analytical methods for studying it.

Herein, we cover the biophysical properties of the C-terminus; different cellular mechanisms that produce a staggering number of C-termini, the C-terminal sequence patterns, their conservation, and evolution.

Explore N-terminus and C-terminus in proteins with Creative Proteomics's comprehensive guide, covering principles, methods, and detailed analysis.

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal end, or COOH-terminus) of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH).

Proteins, comprised of elongated sequences of amino acids, feature distinct terminal ends known as the N-terminus and C-terminus. These terminal points not only mark the inception and conclusion of a protein but also play pivotal roles in its synthesis, configuration, and …

Alternative splicing and proteolysis increase the diversity of proteins and peptides in cells with unique C-termini. The C-termini of proteins contain minimotifs, short peptides with an encoded function generally characterized as binding, posttranslational modifications, and trafficking.

Apr 6, 2016 · All translated proteins end with a carboxylic acid commonly called the C-terminus. Many short functional sequences (minimotifs) are located on or immediately proximal to the C-terminus. However, information about the function of protein C-termini has not been consolidated into a single source.

Abstract Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by …