The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes. [1] [2] [3] The term was coined by Carolyn R. Bertozzi in 2003.

Nov 30, 2021 · Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms. In this review, we summarize the most common reactions used in bioorthogonal methods, their relative advantages and disadvantages, and their frequency of occurrence in the published literature.

Apr 15, 2021 · Bioorthogonal chemistry encompasses a class of high-yielding rapid and selective chemical reactions that proceed in biological environments, with little or no reactivity towards endogenous...

Aug 10, 2023 · Bioorthogonal chemistry is well equipped to augment other powerful biological techniques. The pairing of bioorthogonal chemistry and CRISPR led to a greater understanding of regulatory mechanisms at both the genomic and enzymatic levels.

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions towards endogenous functional groups.

Dec 15, 2021 · Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms. In this review, we summarize the most common reactions used in bioorthogonal methods, their relative advantages and disadvantages, and their frequenc …

Jan 9, 2024 · ‘Bioorthogonal chemistry’ is a term coined in 2003 by American Chemist & 2022 Nobel Prize Laureate Carolyn Bertozzi. It encompasses a set of chemical reactions which can occur within biological environments, whilst exerting minimal effect on native biomolecules or interference with native biochemical processes of the host organism - these ...

Nov 30, 2022 · Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms. It allows organic synthesis that is traditionally performed in a laboratory to be performed in live cells.

Bioorthogonal reactions have found widespread use in chemical biology. This article gives a brief outlook on the future of the field, outlining emerging areas and key challenges to overcome.

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions towards endogenous functional groups.