BRCA1 and BRCA2: different roles in a common pathway of …
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair.
BRCA1 - Wikipedia
High BRCA1 may protect cancer cells by acting in a pathway that removes the damages in DNA introduced by the platinum drugs. Thus the level of BRCA1 expression is a potentially important tool for tailoring chemotherapy in lung cancer management.
The role of BRCA1 in DNA damage response - PMC
The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis.
BRCA1- and BRCA2 -Associated Hereditary Breast and Ovarian Cancer
Sep 4, 1998 · BRCA1 encodes breast cancer type 1 susceptibility protein (BRCA1), a phosphoprotein normally located in the nucleus [Chen et al 1996]. BRCA1 interacts with several proteins involved in cellular pathways, including cell-cycle progression, gene transcription regulation, DNA damage response, and ubiquitination [Deng 2006, Rosen et al 2006].
BRCA1: An Endocrine and Metabolic Regulator - PMC - PubMed …
BRCA1 governs important steps of the lipogenetic pathway and has a key role in energy metabolism. BRCA1 interacts with several hormones, including IGF1, estrogens and androgens, cortisol, etc. In addition, BRCA1 seems to be involved in the process of reproduction.
BRCA1: a key player at multiple stages of homologous ... - Springer
May 27, 2021 · BRCA1 directs DSB repair pathway choice towards HR by promoting DNA end resection that generates single-stranded DNA (ssDNA). BRCA1 also facilitates the formation of RAD51-ssDNA presynaptic filaments, important intermediates that are required for RAD51-mediated strand invasion.
BRCA1 and S Phase DNA Repair Pathways Restrict LINE-1 ...
In particular BRCA1, an E3 ubiquitin ligase with a key role in several DNA repair pathways, directly affects L1 retrotransposition frequency and structure and also plays a distinct role in controlling L1 ORF2 protein translation through L1 mRNA binding.
BRCA1 Pathway - Abeomics
BRCA1 is a tumor suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. Loss of the tumor suppressor BRCA1 results in profound chromosomal instability. As a tumor suppressor, BRCA1 exerts a pleiotropic effect, playing a role in the maintenance of genomic integrity.
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and
Feb 24, 2020 · In this Review, we focus on two key factors of the HR pathway in humans: breast cancer type 1 susceptibility protein (BRCA1) and its obligatory partner BRCA1-associated RING domain protein...
BRCA1 and BRCA2: different roles in a common pathway of …
Dec 23, 2011 · The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in...