The roles and regulatory mechanisms of TGF-β and BMP ... - Nature
Jan 24, 2024 · TGF-βs and BMPs transduce signals through SMAD-dependent and -independent pathways; specifically, they recruit different receptor heterotetramers and R-Smad complexes, resulting in unique...
Control of neuronal excitation–inhibition balance by BMP–SMAD1 ...
Apr 17, 2024 · PV-interneuron-specific disruption of BMP2–SMAD1 signalling is accompanied by a loss of glutamatergic innervation in PV cells, underdeveloped perineuronal nets and decreased...
BMP-Smad 1/5/8 signalling in the development of the nervous system
We describe how, following neural tube closure, the most dorsal aspect of the tube becomes a signalling centre for BMPs, which directs the pattern of the development of the dorsal spinal cord (SC), through the action of Smad1, Smad5 and Smad8.
The role of Smads in BMP signaling - PubMed
May 1, 2003 · Recent progresses in studying the BMP signaling reveal that a cytoplasmic protein family, Smad, plays a central role in mediating the biological effects of BMPs.
Smad4 controls signaling robustness and morphogenesis by ... - Nature
Nov 4, 2021 · We demonstrate that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling. However, unexpectedly, Nodal signaling is maintained, but lacks...
Frontiers | The Cross-Talks Among Bone Morphogenetic Protein (BMP …
Mar 14, 2022 · The cross-talk between IL-6 family members and BMPs induces astrocyte development in primary fetal neural progenitor and neuroepithelial cells in two ways: (1) formation of STAT3/Smad1/p300 transcriptional complex; and (2) …
Genome-wide mechanisms of Smad binding - PMC - PubMed …
In this review, we discuss current knowledge of cell-type-specific binding patterns of Smad proteins and mechanisms of transcriptional regulation obtained from recent ChIP-chip/ChIP-seq studies (Supplementary Table 1). We also highlight applications of the genome-wide analyses for cancer research.
BMP-SMAD signaling: From pluripotent stem cells to …
Feb 1, 2016 · This includes disease modeling when the hPSCs are derived from patients or drug screens for diseases of mesodermal organs. Here, we review the role of the BMP-SMAD signaling pathway in pluripotent stem cells and during mesoderm differentiation with focus on the cells that make up the cardiovascular system. 1.
The Smad Dependent TGF-β and BMP Signaling Pathway in Bone …
May 5, 2021 · Smad mediates the signal transduction in TGF-β and BMP signaling pathway that affects both osteoblast and osteoclast functions, and therefore plays a critical role in the regulation of bone remodeling.
TGF-β/SMAD signaling regulation of mesenchymal stem cells …
Jan 29, 2020 · The formation of mature adipocytes requires adipocyte commitment of MSCs and adipocyte differentiation. It is now established that TGF-β/SMAD signaling has a dual role in the adipocyte differentiation process. BMPs signaling promotes the mature of adipocytes while TGF-βs signaling inhibits it.
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