AXIN2 Gene - GeneCards | AXIN2 Protein | AXIN2 Antibody
Oct 1, 2024 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
The AXIN2 Gene and Cancer Risk - Everyday Health
Aug 1, 2022 · What Is the AXIN2 Gene? AXIN2 is a gene that you inherit from your parents. If you develop changes, or mutations, in this gene, it won’t function the way it should. If You Carry an AXIN2 Gene...
An aggregon in conductin/axin2 regulates Wnt/β-catenin ... - Nature
Sep 18, 2019 · Activation of human conductin, i.e. axin2, by increasing its polymerization holds potential for cancer therapy. Elevated β-catenin signaling is a hallmark of colorectal cancer with more than 90%...
Canonical Wnt suppressor, Axin2, promotes colon carcinoma
Jul 10, 2012 · Silencing Axin2 expression decreases Snail1 activity, reverses EMT, and inhibits CRC invasive and metastatic activities in concert with global effects on the Wnt-regulated cancer cell transcriptome.
AXIN2 axin 2 [Homo sapiens (human)] - Gene - NCBI
Sep 19, 2024 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Variations in AXIN2 predict risk and prognosis of colorectal cancer
Oct 16, 2019 · These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.
Activation of AXIN2 Expression by β-Catenin-T Cell Factor
Expression of AXIN2 / Axil was strongly repressed in cancer cells by restoration of wild type adenomatous polyposis coli function or expression of a dominant negative form of T cell factor (TCF)-4. TCF binding sites in the AXIN2 promoter played a key role in the ability of β-catenin to activate AXIN2 transcription.
The roles of AXIN2 in tumorigenesis and epigenetic regulation
Dec 13, 2014 · AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on.
The roles of AXIN2 in tumorigenesis and epigenetic regulation
AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, …
Entry - *604025 - AXIS INHIBITOR 2; AXIN2 - OMIM
Nov 28, 2017 · The predicted 843-amino acid AXIN2 protein is 89% identical to rat axil. Like axil, AXIN2 contains RGS-signaling (see 602517), GSK-binding, beta-catenin-binding, and Dsh (Drosophila dishevelled; see 601365) domains.
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