AURKA Gene - GeneCards | AURKA Protein | AURKA Antibody
Oct 1, 2024 · NCBI Gene Summary for AURKA Gene. The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis.
Aurora kinase A, a synthetic lethal target for precision cancer ...
May 28, 2021 · AURKA is a serine/threonine kinase involved in a number of central biological processes, such as the G2/M transition, mitotic spindle assembly, and DNA replication. This review introduces...
Targeting AURKA in Cancer: molecular mechanisms and …
Jan 15, 2021 · AURKA promotes tumorigenesis by participating in the cancer cell proliferation, epithelial-mesenchymal transition (EMT), metastasis, apoptosis, and self-renewal of cancer stem cells.
Targeting AURKA in Cancer: molecular mechanisms and ... - PubMed
Jan 15, 2021 · AURKA shows significantly higher expression in cancer tissues than in normal control tissues for multiple tumor types according to the TCGA database. Activation of AURKA has been demonstrated to play an important role in a wide range of cancers, and numerous AURKA substrates have been identified.
Elevated expression of Aurora-A/AURKA in breast cancer …
Aug 28, 2024 · Aurora kinase A (AURKA) is reported to be overexpressed in breast cancer. In addition to its role in regulating cell cycle and mitosis, studies have reported AURKA involvements in oncogenic signaling in suppressing BRCA1 and BRCA2.
Aurora kinase A/AURKA functionally interacts with the ... - Nature
Jun 29, 2023 · We then demonstrate that AURKA functionally interacts with the mitochondrial Complex V core subunits ATP5F1A and ATP5F1B.
Post-transcriptional control drives Aurora kinase A expression in …
3 days ago · Introduction. AURKA is a key regulator of the cell cycle, controlling centrosome maturation and mitotic spindle assembly [].AURKA is overexpressed and represents a marker of poor prognosis in a broad range of human malignancies [2–4].Because of the significant association between high AURKA expression and cancer progression, poor prognosis, and …
Insights into the non-mitotic functions of Aurora kinase A
Sep 27, 2019 · AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy uncovered several non-mitotic roles as well.
Insights into the non-mitotic functions of Aurora kinase A: more …
Sep 27, 2019 · AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy uncovered several non-mitotic roles as well.
AURKA aurora kinase A [ (human)] - National Center for …
Aurora Kinase A Is an Independent Predictor of Invasive Recurrence in Breast Ductal Carcinoma in situ. Revisiting degron motifs in human AURKA required for its targeting by APC/C [FZR1]. Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles.
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