Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...

In this review, we address the current use of asparaginase in the treatment of ALL, with an emphasis on its role in the treatment of adults, key clinical trials, recognition and management of toxicities, and ongoing directions of study. Keywords: acute lymphoblastic leukemia, ALL, adult, asparaginase, pegaspargase.

Dec 4, 2024 · Asparaginase Erwinia chrysanthemi is a cancer medicine. Erwinase is used to treat acute lymphoblastic leukemia in adults and children at least 4 months old who have become allergic to other forms of asparaginase such as Elspar, Oncaspar or Rylaze.

May 26, 2023 · Asparaginase is a type of chemotherapy. It is a treatment for acute lymphoblastic leukaemia (ALL). Find out about how you have it, possible side effects and other important information.

Asparaginase is widely used in chemotherapeutic regimens for the treatment of acute lymphoblastic leukemia (ALL) and has led to a substantial improvement in cure rates, especially in children. Optimal therapeutic effects depend on a complete and …

L-asparaginase (ASNase) is one of the main drugs used and causes death of leukemic cells by systematically depleting the non-essential amino acid asparagine.

Feb 25, 2020 · What is asparaginase used for? Asparaginase is used to treat a type of leukemia. If you are allergic to asparaginase; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If asparaginase caused bleeding, a blood clot, or an irritated pancreas before.

asparaginase An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in ...

Asparaginase is FDA approved in combination with chemotherapy to treat people who have acute lymphoblastic leukemia.

Asparaginase is a bacterial enzyme that is used as an antineoplastic agent, largely in the therapy of acute lymphocytic leukemia (ALL). Asparaginase has many side effects, one of which is hepatic injury that is characterized by inhibition of hepatic protein synthesis, marked cholestasis and steatosis, which is usually reversible but can be ...