Aminoglycosides are a class of antibiotics used mainly in the treatment of aerobic gram-negative bacilli infections, although they are also effective against other bacteria including Staphylococci and Mycobacterium tuberculosis. They are often used in combination with other antibiotics.

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). [1][2] The term can also refer more generally to any organic molecule that contains amino sugar substructures.

Aminoglycosides are infrequently used alone, except when used for plague and tularemia. They are usually used with a broad-spectrum beta-lactam for severe infection suspected to be due to a gram-negative bacillary species.

Jul 17, 2023 · Although not a new class of antimicrobials, aminoglycosides have continued to prove their clinical value in fighting infections. Aminoglycosides have a broad spectrum of activity covering aerobic organisms, including gram-negative bacteria and mycobacteria.

This topic will review basic issues related to the clinical use of parenteral aminoglycosides, including mechanism of action, spectrum of activity, and adverse effects. Dosing and monitoring of aminoglycosides and administration in certain patient populations are discussed elsewhere.

Aminoglycosides are potent, broad-spectrum antibiotics that act through inhibition of protein synthesis. The class has been a cornerstone of antibacterial chemotherapy since streptomycin was first isolated from Streptomyces griseus and introduced into clinical use in 1944.

Aminoglycosides are a class of antibiotics used to treat serious bacterial infections, such as those caused by gram-negative bacteria (especially Pseudomonas aeruginosa). Aminoglycosides include the following: Amikacin. Gentamicin. Kanamycin. …