May 13, 2020 · Amide: Metabolized in the liver like most other drugs, very low incidence of allergy. Individuals with liver disease or low liver function will have a hard time metabolizing the drug and more drug free in the body increasing its toxicity.

A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes unconsciousness. [1]

Jul 5, 2017 · The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work.

Aug 28, 2023 · Commonly used local anesthetics in clinical practice include the following: Amino Amides. Amino Esters. Because of the variable pharmacodynamics, pharmacokinetics, and toxicity profile of the various local anesthesia agents, …

Sep 3, 2017 · Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.

Nov 17, 2022 · Amide local anesthetics are frequently employed for pain management during minor surgical procedures. Local anesthesia induces a temporary loss of sensation, including pain, without affecting consciousness. It works by blocking the rapid influx of sodium ions within nerve fibers, which is essential for generating nerve impulses.

Jan 23, 2025 · Most local anesthetics commonly used in dental procedures belong to the amide group, such as lidocaine, articaine, mepivacaine, and bupivacaine. Procaine, benzocaine, and cocaine belong to the ester group. [2]

Jul 17, 2019 · Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated Na + channels. In doing so, they inhibit action potentials in nociceptive fibres and so block the transmission of pain impulses.

5 days ago · Amide anesthetics, including lidocaine and bupivacaine, have a prolonged absorption phase due to their higher affinity for plasma proteins like α1-acid glycoprotein. This binding decreases free drug availability, extending duration and systemic effects. Lipid solubility also plays a role. Highly lipophilic agents, such as bupivacaine ...

Amide local anesthetics are commonly used for pain control during minor surgery. Local anesthesia causes a temporary loss of sensation, including pain, without depressing the consciousness. It acts within nerve fibers to inhibit the rapid inflow of sodium necessary for impulse generation.