神经元、星形胶质细胞和少突胶质细胞标记物 | Cell Signaling …
醛脱氢酶 1 家族成员 l1 (aldh1l1) 是叶酸代谢中的一种关键酶，因此在细胞代谢和增殖的调节方面起着重要作用。已在肿瘤中发现 aldh1l1 下调，导致对癌细胞增殖的抑制减弱。靶向 aldh1l1 的抗体标记大脑中星形胶质细胞的细胞浆，可有效染色细胞体和这些细胞的过程。
ALDH1L1 Gene - GeneCards | AL1L1 Protein | AL1L1 Antibody
Oct 1, 2024 · ALDH1L1 (Aldehyde Dehydrogenase 1 Family Member L1) is a Protein Coding gene. Diseases associated with ALDH1L1 include Focal Dermal Hypoplasia and Intellectual Developmental Disorder, Autosomal Recessive 59. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism.
ALDH1L1 - Wikipedia
10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene. [5] The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate , and water to tetrahydrofolate, NADPH, and carbon dioxide.
星形胶质细胞标记物 - Abcam中文官网
星形胶质细胞是中枢神经系统中呈星形的多功能胶质细胞，对脑部的发育、生理机能及病理至关重要。阅读本文了解如何选择最佳的星形胶质细胞标记物包括gfap和aldh1l1。
Improved tools to study astrocytes - Nature Reviews Neuroscience
Feb 10, 2020 · From this study, Aldh1l1, which encodes aldehyde dehydrogenase family 1 member L1 (ALDH1L1), emerged as a pan astrocyte marker and was confirmed with Aldh1l1-EGFP reporter mice that...
ALDH1L1 aldehyde dehydrogenase 1 family member L1 [ (human)]
Oct 28, 2024 · One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression. Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell …
实验鼠知识库：星形胶质细胞小鼠—Aldh1l1-Cre/ERT2 - 知乎
Mar 29, 2023 · 使用 Aldh1l1-CreERT2 小鼠，科研工作者可特异性标记神经系统中星形胶质细胞，进而通过基因干扰、基因过表达等手段特异性探究单一脑区内胶质细胞及其内部某分子的功能，亦有潜力开展神经转分化相关基因治疗。
ALDH1L1 aldehyde dehydrogenase 1 family member L1 [Homo …
Aug 27, 2024 · Title: ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma. ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer
神经血管单位的体内靶向:挑战与进展——大脑周细胞、星形胶质细 …
Sep 19, 2022 · GFAP和ALDH1L1是星形胶质细胞最特异的遗传驱动因子。根据大脑区域，GFAP Cre小鼠模型(hGFAP-CreERT2xAi14)已被表征为具有50%至89%的星形胶质细胞覆盖率，对星形胶质细胞的特异性在52%至92%之间。
南方医科大学高天明院士团队揭示星形胶质细胞通过乙酰胆碱受 …
利用Cre-loxp重组系统，研究人员将ALDH1l1-creERT2和Chrm1 fl/fl小鼠进行杂交，获得在星形胶质细胞上特异敲除Chrm1的转基因小鼠（以下称为ALDH1l1-Chrm1fl/fl），同时还对ALDH1l1-Chrm1fl/fl小鼠进行了mRNA、蛋白及功能水平上的验证（图1E-J）。