Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication. It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds , as eye drops to treat eye redness due to minor irritation, and (in the United States) as a prescription topical cream to treat ...

Such combination use adds beneficial effects: the vasoconstrictor counteracts the local anesthetic agent's vasodilatory action, thereby constricting dilated arterioles and reducing blood flow to the application area. 2,16 Oxymetazoline relieves nasal congestion by vasoconstricting the respiratory microvasculature, in both resistance and ...

Mechanism of Action. Oxymetazoline is a selective α 1 adrenergic receptor agonist, which mediates vascular smooth muscle contraction and subsequent vasoconstriction of small vessels in the skin.

Feb 17, 2020 · Mechanism of Action. Stimulates alpha-adrenergic receptors in the arterioles of the nasal mucosa to produce vasoconstriction. Pharmacokinetics/Pharmacodynamics Onset of Action. Within 10 minutes (Chua 1989) Duration of Action. Up to 12 hours (Chua 1989) Use: Labeled Indications

OXYMETAZOLINE [AFRIN] DRUG Direct CLASSIFICATION Imidazoline Derivative -Acting Sympathomimetic Adrenergic Receptor Agonist Decongestant Agent MECHANISM OF ACTION Oxymetazoline is an adrenergic α í- and α î-agonist and a direct-acting sympathomimetic drug. Stimulates adrenergic receptors,

A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. It has a role as an alpha-adrenergic agonist, a sympathomimetic agent, a nasal decongestant and a vasoconstrictor agent.

Mechanism of Action. Stimulates α-adrenergic recepter in arterioles of nasal mucosa, produce vasoconstriction; Comments See Also References

MAOIs cause norepinephrine accumulation within adrenergic neurons. Significant hypertension can result if coadministered with alpha1 agonists. ozanimod increases toxicity of oxymetazoline...

Mechanism of action: Decongestants work by stimulating alpha-adrenergic receptors, causing vasoconstriction of blood vessels in the nasal passages. This reduces blood flow and swelling in the nasal mucosa, leading to decreased congestion and improved airflow.

Its active component is an alpha-adrenomimetic, narrowing the vessels, reducing edema and hyperemia of the mucous membranes of the nasopharynx in the rhinitis, which facilitates the breathing process. The preparation is produced in the form of a spray, packed in 15 ml vials.