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  1. Mayo Clinic
    https://www.mayoclinic.org › diseases-conditions › acromegaly › symptoms-causes

    Acromegaly - Symptoms and causes - Mayo Clinic

    • Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When you have too much growth hormone, your bones increase in size. In … See more

    Symptoms

    A common sign of acromegaly is enlarged hands and feet. For example, you may notice that you aren't able to put on rings that used to fit, and that your shoe size has progressive… See more

    Mayo Clinic
    Causes

    Acromegaly occurs when the pituitary gland produces too much growth hormone (GH) over a long period of time. The pituitary gland is a small gland at the base of your brain, behi… See more

    Mayo Clinic
    Risk Factors

    People who have a rare genetic condition called multiple endocrine neoplasia, type 1 (MEN 1), have a higher risk of developing acromegaly. In MEN 1, the endocrine glands — u… See more

    Mayo Clinic
    Complications

    If left untreated, acromegaly can lead to major health problems. Complications may include: 1. High blood pressure (hypertension). 2. High cholesterol. 3. Heart problems, … See more

    Mayo Clinic
    What is acral melanoma?
    Acral melanoma is a subtype of cutaneous melanoma occurring in glabrous acral skin, such as the palms, soles, and nail units, especially the nail matrix . The most common clinicohistological type is acral lentiginous melanoma based on the lentiginous pattern on histology, and was first discussed by Reed in 1976.
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    Table of Contents
    Symptoms
    Causes
    Risk Factors
    Complications
    What is acral melanoma?
     
  1. Studies of Acral Growth
    National Center for Biotechnology Information
    Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective
    Acral melanocytic neoplasms, including acral melanocytic nevus and acral melanoma, are common melanocytic lesions in Asian populations. Both lesions occur on the volar surface of the hands and feet, and on nail units. Acral melanocytic nevi occur on the arch area of the sole, whereas acral melanomas...
    Author: Sanghyun Par…
    Published: 2022/09
    Publication: Dermatop…
    National Center for Biotechnology Information
    Acromegaly: a challenging condition to diagnose
    Acromegaly is an uncommon, chronic disease, characterized by hypersecretion of a pituitary growth hormone by somatotroph adenomas, along with increased levels of insulin-like growth factor-1. Although acromegaly presents a wide array of clinical manifestations, the salient symptoms include acral and...
    Author: Salma AlDallal
    Published: 2018
    Publication: Int J Gen …
    National Center for Biotechnology Information
    Acromegaly - StatPearls - NCBI Bookshelf
    Acromegaly is a rare disorder caused by excessive growth hormone production (GH), most commonly from an adenoma of the anterior pituitary gland. The resulting production of insulin-like growth factor 1 (IGF-1) causes the characteristic overgrowth of certain tissues resulting in coarsening of facial ...
    Author: Oluwaseun O. …
    Published: 2023/02/02
    Affiliations: Medway N…
    PubMed
    Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone
    Objectives: To investigate the effects of growth hormone (GH) therapy on craniofacial growth and body proportions in growth hormone deficient children. Study design: By using a cross-sectional study design, we investigated GH effects on craniofacial growth with photographic facial morphometrics,...
    Author: David G Segal
    Published: 2004/4
    Keywords: To investig…
    ScienceDirect
    Craniofacial and acral growth responses in growth hormone-deficient children treated with growth hormone☆
    Objectives To investigate the effects of growth hormone (GH) therapy on craniofacial growth and body proportions in growth hormone deficient children. Study design By using a cross-sectional study design, we investigated GH effects on craniofacial growth with photographic facial morphometrics...
    Published: 2004/04/01
    Cited By: 0
    Keywords: GH Growth …
  2. Mayo Clinic Proceedings
    https://www.mayoclinicproceedings.org › art…

    Diagnosis and Treatment of Acromegaly: An Update

    Acromegaly is typically caused by a growth hormone–secreting pituitary adenoma, driving excess secretion of insulin-like growth factor 1. Acromegaly may result in a variety of cardiovascular, respiratory, endocrine, metabolic, …

  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Acral Melanocytic Neoplasms: A Comprehensive Review of Acral …

  4. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Clinical Manifestations and Diagnosis of Acromegaly - PMC

  5. Nature
    https://www.nature.com › articles

    Acromegaly - Nature Reviews Disease Primers

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Acromegaly: a challenging condition to diagnose - PMC

  7. Springer
    https://link.springer.com › article

    Acromegaly: clinical features at diagnosis | Pituitary

    Nov 3, 2016 · Excessive growth of hands and feet (predominantly due to soft tissue swelling) is present in the vast majority of acromegalic patients. Gigantism accounts for up to 5% of cases and occurs when the excess of GH becomes …

  8. BMJ Best Practice
    https://bestpractice.bmj.com › topics › en-us

    Symptoms, diagnosis and treatment - BMJ Best Practice US

    Acromegaly - Management Approach | BMJ Best Practice
    Acromegaly - Monitoring | BMJ Best Practice US
    Acromegaly - History and exam | BMJ Best Practice
    Acromegaly - Complications | BMJ Best Practice
    See more results
  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › books

    Acromegaly - StatPearls - NCBI Bookshelf

    Sep 25, 2020 · Acromegaly is a disorder caused by excessive growth hormone production from the anterior pituitary gland, resulting in excessive growth of body tissues and other metabolic dysfunctions. The causes of acromegaly can be …

  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Acral enlargement without growth hormone excess: a clinical