The MAPK and AMPK signalings: interplay and implication in
Aug 17, 2020 · The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting ...
ERK signalling: a master regulator of cell behaviour, life and fate
Jun 23, 2020 · ERK and RSK interfere with AMPK activation by inhibiting LKB1 and thus suppress PGC1α-dependent mitochondrial biogenesis. Conversely, AMPK inhibits ERK signalling by phosphorylating and...
Inhibitory cross-talk between the AMPK and ERK pathways …
Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes. These findings suggest that ERK signalling plays an important role in the regulation of insulin signals in muscle cells under ER stress.
Inhibitory cross-talk between the AMPK and ERK pathways …
AMP-Activated Protein Kinases. Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes.
The MAPK and AMPK signalings: interplay and implication in …
Aug 17, 2020 · Blocking hyperactive Ras/RAF/MEK/ERK (MAPK) signaling by MAPK inhibitors in Ras/RAF-mutated cancer cells elevates autophagic flux through relieving LKB1/AMPK/ULK1 axis and inhibiting glycolysis and mitochondrial functions, which leads to drug tolerance and/or acquired resistance.
Inhibitory cross-talk between the AMPK and ERK pathways
Feb 4, 2013 · Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes. These findings suggest that ERK signalling plays an important role in the regulation of insulin signals in muscle cells under ER stress.
Unraveling the interplay between RAS/RAF/MEK/ERK signaling …
Nov 1, 2023 · The overactivation of ERK caused RNF44 expression to be upregulated on transcription factor CREB, and this caused UPS to degrade AMPK, ultimately leading to impaired autophagy. The degradation of AMPK is behind the strong arginine-dependent metabolism, that was displayed by these cells, a state that indicated an increased sensitivity to ...
Inhibition of IL-11 signalling extends mammalian healthspan and ...
Jul 17, 2024 · IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
AMP-activated protein kinase: the current landscape for drug ...
Mar 13, 2019 · AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis that is activated by physiological regulators associated with health and longevity.
A novel MEK-ERK-AMPK signaling axis controls chemokine ... - PubMed
Jan 9, 2015 · We have analyzed the involvement of the AMP-dependent kinase (AMPK) in the control of CCR7-dependent survival. A pro-apoptotic role for AMPK is suggested by the finding that pharmacological activators induce apoptosis, whereas knocking down of AMPK with siRNA extends mDC survival.
- Some results have been removed