Mechanisms of ADC Toxicity and Strategies to Increase ADC …
Jan 24, 2023 · In this manuscript, we provide an overview of the main mechanisms underlying ADC toxicity, and we provide a summary of the clinical safety profile of approved ADCs. Additionally, the manuscript discusses approaches to mitigating or preventing ADC toxicities.
Mechanisms of ADC Toxicity and Strategies to Increase ADC
Jan 24, 2023 · In this manuscript, we review the fundamental mechanisms contributing to ADC toxicity, we summarize common ADC treatment-related adverse events, and we discuss several approaches to mitigating ADC toxicity.
Rapid conjugation of antibodies to toxins to select candidates for …
Jun 1, 2020 · Antibody-Drug Conjugates (ADCs) developed as a targeted treatment approach to deliver toxins directly to cancer cells are one of the fastest growing classes of oncology therapeutics, with eight...
Exploring the next generation of antibody–drug conjugates
Jan 8, 2024 · An ADC consists of a monoclonal antibody and a potent cytotoxic payload connected through a chemical linker. This molecular design combines the target specificity and long circulation half-life...
Rise of Antibody-Drug Conjugates: The Present and Future
May 25, 2023 · Antibody-drug conjugates (ADCs) embody a simple, but elegant, vision for cancer therapy—the delivery of a potent cytotoxic agent to tumor cells with minimal damage to normal cells—so-called smart chemo.
Optimizing the safety of antibody–drug conjugates for ... - Nature
Jun 9, 2023 · In this Review, we describe the determinants of the toxicities of ADCs in patients with solid tumours, highlighting key strategies that are expected to improve tolerability and enable...
Analytical Methods for the Detection and Quantification of ADCs …
Dec 14, 2020 · By merging the specific binding properties of antibodies to the potency of small molecules, ADCs are designed to selectively deliver cell-killing agents to targeted pathogenic tissues, while limiting systemic toxicity.
Effects of antibody, drug and linker on the preclinical and clinical ...
Apr 5, 2016 · The majority of ADC toxicity is thought to be derived from the payload. Normal, rapidly dividing cells are at risk of toxicity from microtubule inhibitors as they exert their cytotoxic effects on rapidly proliferating cells.
Determination of ADC Cytotoxicity in Immortalized Human Cell …
Cytotoxicity assay is an essential experiment during the development of drug molecules like antibody-drug conjugate (ADC), which influence cell proliferation or demonstrate direct killing effect. It is a very useful tool to triage promising ADC candidates, predict in-vivo efficacy of ADCs, and evaluate the specificity of ADCs.
Potential mechanisms of target-independent uptake and toxicity …
Aug 1, 2019 · In this article, we review potential mechanisms of target-independent ADC uptake and toxicity in normal cells, as well as discuss components of ADCs which may influence these mechanisms.
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