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  1. Studies of ACTH Camp
    PubMed
    Biochemical and Ionic signaling mechanisms for ACTH-stimulated cortisol production
    Adrenocorticotropic hormone (ACTH)-stimulated cortisol production by adrenal zona fasciculata cells requires coordinated biochemical and ionic signaling mechanisms that employ adenosine 3', 5'-cyclic monophosphate (cAMP) and Ca(2+) as intracellular messengers. As the primary messenger generated in r...
    Author: John J Enyeart
    Published: 2005
    Keywords: National In…
    National Center for Biotechnology Information
    Adrenocorticotrophic hormone is a potent regulator of gene expression in human adrenal cells
    The adrenal glands are the primary source of minerocorticoids, glucocorticoids and the so-called adrenal androgens. Under physiological conditions cortisol and adrenal androgen synthesis are controlled primarily by adrenocorticotrophic hormone (ACTH). Although it has been established that ACTH can s...
    Author: Yewei Xing, C…
    Published: 2010/07
    DOI: 10.1677/JME-10-…
    ScienceDirect
    Mechanistic profiling of the cAMP-dependent steroidogenic pathway in the H295R endocrine disrupter screening system: New endpoints for toxicity testing
    The need for implementation of effects on steroid synthesis and hormone processing in screening batteries of endocrine disruptive compounds is widely acknowledged. In this perspective, hormone profiling in the H295R adrenocortical cell system is extensively examined and recently OECD validated (TG 4...
    Published: 2012/01/25
    Cited By: 0
    Keywords: ACTH adre…
    PubMed
    ACTH receptor: ectopic expression, activity and signaling
    Failure in obtaining expression of functional adrenocorticotropic hormone receptor (ACTHR, or melanocortin 2 receptor, MC2R) in non-adrenal cells has hindered molecular analysis of ACTH signaling pathways. Here, we ectopically expressed the mouse ACTHR in Balb/c mouse 3T3 fibroblasts to analyze ACTH...
    Author: Fábio Luís Forti
    Published: 2006/12
    Keywords: National In…
    National Center for Biotechnology Information
    ACTH Inhibits bTREK-1 K+ Channels through Multiple cAMP-dependent Signaling Pathways
    Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K+ channels that set the resting membrane potential and function pivotally in the physiology of cortisol secretion. Inhibition of these K+ channels by adrenocorticotropic hormone (ACTH) or cAMP is coupled to depolarization and Ca2+ entry. T...
    Author: Haiyan Liu, Ju…
    Published: 2008/08
    Publication: J Gen Ph…
  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › sites › books

    Physiology, Adrenocorticotropic Hormone (ACTH) - StatPearls

  3. Journal of Biological Chemistry
    https://www.jbc.org › article › fulltext

    cAMP-dependent Protein Kinase Enhances CYP17 …

    Steroid hormone biosynthesis in the adrenal cortex is controlled by adrenocorticotropin (ACTH), which increases intracellular cAMP, resulting in …

    • Author: Marion B. Sewer, Michael R. Waterman
    • Publish Year: 2003
  4. Analytical Science Journals
    https://analyticalsciencejournals.onlinelibrary.wiley.com › doi › pdf
    [PDF]

    Mechanism of action of ACTH: Beyond cAMP - Analytical …

  5. Cleveland Clinic
    https://my.clevelandclinic.org › health › articles

    Adrenocorticotropic Hormone (ACTH): What It Is & Function

  6. Journal of Biological Chemistry
    https://www.jbc.org › article › fulltext

    ACTH Induces Cav3.2 Current and mRNA by cAMP …

    In this study, we examined the regulation of CACNA1H mRNA and corresponding Ca v 3.2 Ca 2+ currents in AZF cells by ACTH, cAMP analogs, and their …

    • Author: Haiyan Liu, Judith A. Enyeart, John Joseph Enyeart
    • Publish Year: 2010
  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Biochemical and Ionic signaling mechanisms for ACTH-stimulated …

  8. People also ask
    How does ACTH work?
    The release of ACTH triggers your adrenal glands to produce cortisol, the “stress hormone,” and androgens (a group of sex hormones). Hormones are chemicals that coordinate different functions in your body by carrying messages through your blood to your organs, skin, muscles and other tissues.

    Adrenocorticotropic Hormone (ACTH): What It Is & Function

    my.clevelandclinic.org
    What does ACTH stand for?
    A note from Cleveland Clinic Adrenocorticotropic hormone (ACTH) is essential for regulating your cortisol levels. If you’re experiencing symptoms of high or low cortisol levels, such as weight gain or loss and high or low blood pressure, respectively, it’s important to contact your healthcare provider.

    Adrenocorticotropic Hormone (ACTH): What It Is & Function

    my.clevelandclinic.org
    How does ACTH receptor activation work in AZF cells?
    In this scheme, background K (+) channels act pivotally by transducing a hormonal signal at the cell membrane to an ionic signal, leading to depolarization-dependent Ca (2+) entry. In this way, ACTH receptor activation increases cAMP and Ca (2+) in the AZF cell, yielding the full steroidogenic response.

    Biochemical and Ionic signaling mechanisms for ACTH-stimulated ... - P…

    pubmed.ncbi.nlm.nih.gov
    What is ACTH-stimulated cortisol produced by adrenal zona fasciculata cells?
    Adrenocorticotropic hormone (ACTH)-stimulated cortisol production by adrenal zona fasciculata cells requires coordinated biochemical and ionic signaling mechanisms that employ adenosine 3', 5'-cyclic monophosphate (cAMP) and Ca (2+) as intracellular messengers. As the primary messenger generated in r …

    Biochemical and Ionic signaling mechanisms for ACTH-stimulated ... - P…

    pubmed.ncbi.nlm.nih.gov
    Can ACTH cause hypopituitarism?
    Hypopituitarism: This is a rare condition in which there’s a lack (deficiency) of one, multiple or all of the hormones made by your pituitary gland. ACTH can be one of the affected hormones. Any type of damage to your pituitary gland, such as pressure on the gland, surgical damage or radiation therapy, can cause hypopituitarism.

    Adrenocorticotropic Hormone (ACTH): What It Is & Function

    my.clevelandclinic.org
    How does the feedback system control ACTH levels?
    The feedback system that controls ACTH levels involves the following steps: When cortisol levels are low, your hypothalamus releases corticotrophin-releasing hormone (CRH). CRH stimulates your anterior pituitary lobe to release ACTH. ACTH then triggers your adrenal glands, specifically your adrenal cortex, to release cortisol and androgens.

    Adrenocorticotropic Hormone (ACTH): What It Is & Function

    my.clevelandclinic.org
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  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Adrenocorticotrophic hormone is a potent regulator of gene …

  10. endotext.org
    https://www.endotext.org › wp-content › uploads › pdfs › ...
    [PDF]

    ACTH ACTION ON THE ADRENALS - Endotext

  11. Wiley Online Library
    https://onlinelibrary.wiley.com › doi › abs

    Mechanism of action of ACTH: Beyond cAMP - Gallo‐Payet - 2003 ...

  12. Read by QxMD
    https://read.qxmd.com › read › mechanism-of...

    Mechanism of action of ACTH: beyond cAMP | Read by QxMD