Atropine - Wikipedia
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. [6] It is typically given intravenously or by injection into a muscle. [6]
Atropine augments cardiac contractility by inhibiting cAMP …
In the heart, atropine blocks the inhibitory effect of ACh on heart rate and contractility, potentially also leading to tachyarrhythmias 6. These and other prominent effects of atropine have been exclusively attributed to its antagonism at muscarinic receptors 7 , 8 .
Atropine augments cardiac contractility by inhibiting cAMP …
Nov 9, 2017 · In the heart, atropine blocks the inhibitory effect of ACh on heart rate and contractility, potentially also leading to tachyarrhythmias 6.
Acetylcholine-Atropine Interactions: Paradoxical Effects on …
Atropine (ATr) is well known as a cholinergic antagonist, however, at low concentrations ATr could paradoxically accentuate the parasympathetic actions of acetylcholine (ACh). In 22 pentobarbital anesthetized dogs, via a left and right thoracotomy, a leak-proof barrier was attached to …
Interactions of atropine with heterologously expressed and native …
Atropine, a classical muscarinic antagonist, has been reported previously to inhibit neuronal nicotinic acetylcholine receptors (nAChRs). In the present study, the action of atropine has been examined on α3β4 receptors expressed heterologously in Xenopus oocytes and native nAChRs in medial habenula neurons.
Atropine (Muscarinic Receptor Antagonist) - CV Pharmacology
Atropine (Muscarinic Receptor Antagonist) General Pharmacology. The vagus (parasympathetic) nerves that innervate the heart release acetylcholine (ACh) as their primary neurotransmitter. ACh binds to muscarinic receptors (M 2) that are found principally on cells comprising the sinoatrial (SA) and atrioventricular (AV) nodes.
Atropine: Uses, Interactions, Mechanism of Action - DrugBank …
Atropine is an antimuscarinic agent that antagonizes the effects of acetylcholine. 5,6,8 In small doses, atropine slows heart rate, and tachycardia develops due to paralysis of vagal control. Compared to scopolamine , atropine has a more potent and prolonged effect on the heart, intestine and bronchial muscle, but a weaker effect on the iris ...
Atropine - StatPearls - NCBI Bookshelf - National Center for ...
Jun 23, 2023 · Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitoring of atropine.
Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
Parasympatolytics (usually atropine, Fig. 15), that reduce the effects of the accumulated ACh on the cholinergic receptors , and anticonvulsives (usually diazepam, Fig. 15), diminishing neuromuscular seizures , are used as the symptomatic treatment. The causal treatment comprises AChE reactivators that, unlike the symptomatic drugs, regenerate ...
Pharm 101: Atropine • LITFL • Top 200 Drugs
Sep 10, 2020 · Atropine is a tertiary amine alkaloid ester of tropic acid; Competitive, reversible muscarinic ACh receptor antagonist. Binding prevents release of IP3 (inositol triphosphate), DAG (diacyglycerol), and inhibition of adenylyl cyclase, which are caused by muscarinic agonists; Equipotent at M1, M2, M3 receptors; No significant nicotinic effect