Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon ...
Mar 18, 2022 · Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation …
Structural basis for regulation of human acetyl-CoA carboxylase
Jun 13, 2018 · Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, …
Acetyl-CoA Carboxylases and Diseases - Frontiers
Mar 10, 2022 · Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of …
ACC1 determines memory potential of individual CD4 - Nature
Jan 14, 2019 · Our data indicate that fatty acid metabolism directs cell fate determination during the generation of memory CD4+ T cells. ACC1 is a rate-limiting enzyme during fatty acid …
Filament structures unveil the dynamic organization of human
Oct 9, 2024 · The molecular mechanism underlying the dynamic organization of ACCs is largely unknown. Here, we determined the cryo–electron microscopy (EM) structure of human ACC1 …
ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune
ACC1 (acetyl coenzyme A carboxylase 1) is a key enzyme that has been recently found to propagate CD4 + T cell-associated inflammation by mediating de novo fatty acid synthesis; …
ACC1 is overexpressed in liver cancers and contributes to the ...
Acetyl-coenzyme A carboxylase 1 (ACC1) serves a major role in fatty acid synthesis. Previous reports have indicated that ACC1 is a promising drug target for treating human diseases, …
How Does Polymerization Regulate Human Acetyl-CoA …
Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is …
Structural basis for regulation of human acetyl-CoA carboxylase
Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the outer mitochondrial membrane and controls fatty acid β …
Targeting acetyl-CoA carboxylase 1 for cancer therapy - PMC
ACC1 is a key regulator of fatty acid metabolism, making it promising therapeutic targets for multiple metabolic diseases. ACC1 has been regarded as attractive therapeutic targets for non …
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