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  1. The Women's Health Initiative (WHI) is an ongoing study of over 27,000 women that began in 1991, with the most recent analyses suggesting that, when initiated within 10 years of menopause, HRT reduces all-cause mortality and risks of coronary disease, osteoporosis, and dementia; after 10 years the beneficial effects on mortality and coronary heart disease are no longer apparent, though there are decreased risks of hip and...

    en.wikipedia.org/wiki/Hormone_replacement_therapy
    The timeline is important in the sense that it's preferable to start taking HRt within 10 years of menopause or aged under 60 because this is generally accepted as the "window of opportunity" for maximum benefit and least harm. However this also depends on your general health and the type of HRT you take.
    www.menopausematters.co.uk/forum/index.php?to…
    Women who begin hormone therapy at age 60 or older or more than 10 years from the onset of menopause are at greater risk of the above conditions. But if hormone therapy is started before the age of 60 or within 10 years of menopause, the benefits appear to outweigh the risks.
    www.mayoclinic.org/diseases-conditions/menopau…
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  3. Starting or continuing HRT many years after your menopause

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  6. How long can you take HRT? - Medical News Today

  7. Hormone Therapy and Other Treatments for …

    Dec 1, 2016 · The “timing hypothesis” suggests that starting hormone therapy early in menopause (compared with starting it 10 years or more after the onset of menopause) may be cardioprotective because of...

  8. Hormone Therapy for Postmenopausal Women | NEJM

    Jan 29, 2020 · Women younger than 60 years of age or within 10 years after the onset of menopause who have symptomatic menopausal hot flashes or night sweats are most likely to benefit from hormone...