GRADE is a systematic approach to rating the certainty of evidence in systematic reviews and other evidence syntheses. For more information on the GRADE Working Group and how to connect with them, please visit www.gradeworkinggroup.org.

The GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) is a method of assessing the certainty in evidence (also known as quality of evidence or confidence in effect estimates) and the strength of recommendations in health care. [1]

GRADE (Grading of Recommendations, Assessment, Development and Evaluations) is a transparent framework for developing and presenting summaries of evidence and provides a systematic approach for making clinical practice recommendations.

The new GRADE Book is an official publication providing the most up-to-date and accurate description of the GRADE approach proposed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Working Group.

Objectives: The objective of the study is to present the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) conceptual approach to the assessment of certainty of evidence from modeling studies (i.e., certainty associated with model outputs).

The GRADE approach is a system for rating the quality of a body of evidence in systematic reviews and other evidence syntheses, such as health technology assessments, and guidelines and grading recommendations in health care.

Cochrane Handbook for Systematic Reviews of Interventions contains essential guidance for preparing and maintaining Cochrane Reviews of the effects of health interventions. GRADE approach is covered especially in the following chapters: Oher sections of the Cochrane Handbook addressing the GRADE approach: