ETS1 - Wikipedia
In adult humans, Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells. By contrast, knocking Ets1 down causes multiple defects in the immune system.
Review of Ets1 structure, function, and roles in immunity
Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.
ETS1 Gene - GeneCards | ETS1 Protein | ETS1 Antibody
Oct 1, 2024 · ETS1 (ETS Proto-Oncogene 1, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS1 include Jacobsen Syndrome and Hematologic Cancer. Among its related pathways are Cellular responses to stimuli and Cellular Senescence.
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ETS1 is a key transcription factor that drives RANKL ... - Nature
Aug 23, 2022 · Nature Immunology - Tissue-destructive fibroblasts in arthritis are driven by the transcription factor ETS1. Analysis of a cross-tissue, single-cell fibroblast dataset and genetic...
The transcription factor ETS1 is an important regulator of human …
Jul 16, 2020 · By generating ETS1 -deficient human embryonic stem cells and by expressing the dominant-negative ETS1 p27 isoform in cord blood hematopoietic progenitor cells, we show that the transcription factor ETS1 is critically required for human NK cell differentiation.
ETS1 ETS proto-oncogene 1, transcription factor [ (human)]
ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Regulation of MMP9 transcription by ETS1 in immortalized salivary gland epithelial cells of patients with salivary hypofunction and primary Sjogren's syndrome.
VEGF amplifies transcription through ETS1 acetylation to enable ...
Aug 29, 2017 · Here we show that VEGF stimulates RNAPII pause release by stimulating acetylation of ETS1, a master endothelial cell transcriptional regulator.
In the Tumor Microenvironment, ETS1 Is an Oncogenic Immune …
Apr 15, 2022 · We will look into the genetic abnormalities, expression patterns, and survival assessments of ETS1 expression in pancancer patients, as well as the relationship between ETS1 expression and tumor immune infiltration. Finally, we looked into the relationship between PPI and gene functional enrichment. 2.1.