PARP1 - Wikipedia
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly [ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] It is the most abundant of the PARP family of enzymes, accounting for 90% of …
The multifaceted roles of PARP1 in DNA repair and ... - Nature
Jul 5, 2017 · PARP1 is an abundant nuclear protein that post-translationally attaches a negatively charged polymer termed poly (ADP-ribose) (PAR) to itself and to multiple target proteins.
PARP1 Gene - GeneCards | PARP1 Protein | PARP1 Antibody
Oct 2, 2024 · Tocris Summary for PARP1 Gene. Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.
PARP1: Structural insights and pharmacological targets for
Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base excision repair (BER), non-homologous end joining (NHEJ), homologous recombination (HR), and Okazaki-fragment processing …
Poly(ADP-ribose) polymerase inhibition: past, present and ...
Sep 3, 2020 · The nuclear enzyme poly (ADP-ribose) polymerase 1 (PARP1) was first described more than 50 years ago 1, 2, 3 and is now known to play important roles in DNA repair and the...
PARP1 is a versatile factor in the regulation of mRNA ...
Mar 6, 2019 · PARP1 is an abundant nuclear protein with many pleiotropic functions involved in epigenetic and transcriptional controls. Abundance of mRNA depends on the balance between synthesis and...
Multifaceted Role of PARP-1 in DNA Repair and Inflammation ...
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic inflammation may both predispose to cancer development.
PARP1: Structural Insights and Pharmacological Targets for …
Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base excision repair (BER), non-homologous end joining (NHEJ), homologous recombination (HR), and Okazaki-fragment processing pathways.
PARP-1 and its associated nucleases in DNA damage response
Poly (ADP-ribose) (PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to damage sites.
PARP1: Liaison of Chromatin Remodeling and Transcription
Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied member of the PARP superfamily and participates in numerous cellular processes. PARP1 inhibitors have been approved as drugs to treat various cancers in clinics, based on its role in DNA repair.
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