- In this review we summarize the key mechanisms that drive kidney fibrosis, including recent advances in understanding the mechanisms, as well as potential routes for developing novel targeted antifibrotic therapeutics.pubmed.ncbi.nlm.nih.gov/37775469/
Kidney fibrosis: from mechanisms to therapeutic medicines
Mar 17, 2023 · Kidney fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a hallmark manifestation in different progressive CKD; However, at present no antifibrotic...
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Cellular and molecular mechanisms of kidney fibrosis - PubMed
Kidney's histological structure can be divided into three main compartments, all of which can be affected by fibrosis, specifically termed glomerulosclerosis in glomeruli, interstitial fibrosis in …
- Author: Sonja Djudjaj, Peter Boor
- Publish Year: 2019
Mechanisms of kidney fibrosis and routes towards therapy
Jan 1, 2024 · In this review we summarize the key mechanisms that drive kidney fibrosis, including recent advances in understanding the mechanisms, as well as potential routes for …
Kidney fibrosis: from mechanisms to therapeutic medicines
Mar 17, 2023 · In addition, genetics and epigenetics are deeper mechanisms that regulate kidney fibrosis. And the reversible nature of epigenetic changes including DNA methylation, RNA …
Cellular and molecular mechanisms of renal fibrosis
Oct 18, 2011 · This Review outlines our current understanding of the cellular and molecular mechanisms of renal fibrosis, which could offer novel insights into the development of new …
- Author: Youhua Liu
- Publish Year: 2011
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Cellular and molecular mechanisms in kidney fibrosis
Recent insights into the cellular and molecular mechanisms of fibrogenesis herald the promise of new therapies to slow kidney disease progression. This review focuses on new findings that enhance understanding of cellular and molecular …
Insights into the mechanisms of fibrosis and progressive kidney …
Jan 3, 2025 · Progression of chronic kidney disease to kidney fibrosis is a key challenge in nephrology. Several contributions from the past year have shed light not only on the general …
New Aspects of Kidney Fibrosis–From Mechanisms of Injury to …
Jan 12, 2022 · Myofibroblasts are key drivers of kidney fibrosis. This has been shown, for example, by targeting of secreted modular calcium-binding protein 2 (SMOC2), an activator …
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
Several systems, molecules and responses involved in the pathogenesis of the pathological fibrosis of chronic kidney disease (CKD) will be discussed in this review, putting special …
Pathophysiological Mechanisms of Renal Fibrosis: A Review of …
The use of appropriate models for the study of renal fibrosis may provide information that provides an understanding of the pathogenic mechanisms of the causes and progression of the …
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