Open links in new tab
  1. Wikipedia
    https://en.wikipedia.org/wiki/Interleukin_23

    Interleukin 23 - Wikipedia

    • Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. IL-23 is part of the IL-12 family of cytokines. The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R. See more

    SymbolIL23A
    NCBI gene51561
    HGNC15488
    RefSeqNM_016584
    Discovery

    IL-23 was first described by Robert Kastelein and colleagues at the DNAX research institute using a combination of computational, biochemical and cellular immunology approaches. See more

    Function

    IL-23 is an inflammatory cytokine. It has been shown to be a key cytokine for T helper type 17 cell (Th17 cell) maintenance and expansion. Polarisation to a Th17 phenotype is triggered by IL-6 and TGF-β, which activ… See more

    IL-23 inhibitors for treating psoriasis: What to know - Medical News Today
    Medical News Today
    Signalling

    The IL-23 heterodimer binds the receptor complex: the p19 subunit binds IL-23R while the p40 subunit binds IL-12RB1. Receptor binding leads to recruitment of Janus kinase 2 and Tyrosine kinase 2 kinases. … See more

    Wikipedia text under CC-BY-SA license
    Feedback
    Table of Contents
    Quick Facts
    Discovery
    Function
    Signalling
     
  1. PubMed
    https://pubmed.ncbi.nlm.nih.gov/21585245

    Interleukin-23: a key cytokine in inflammatory diseases

  2. Medical News Today
    https://www.medicalnewstoday.com/articles/il-23...

    IL-23 inhibitors for treating psoriasis: What to know - Medical …

  3. Frontiers
    https://www.frontiersin.org/journals/imm…

    IL-23 past, present, and future: a roadmap to …

    Apr 14, 2024 · IL-23 is a cytokine that regulates Th17 and type-17 cells and drives immune-mediated inflammatory diseases, such as psoriasis, psoriatic arthritis, and inflammatory bowel disease. This review summarizes IL-23 …

  4. Johnson & Johnson
    https://www.jnj.com/innovation/what-is-il-23

    What is IL-23? - Johnson & Johnson

  5. The New England Journal of Medicine
    https://www.nejm.org/doi/full/10.1056/NEJ…

    Anti–Interleukin-23 Autoantibodies in Adult-Onset …

    Mar 20, 2024 · Nur S, Sparber F, Lemberg C, et al. IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival. PLoS Pathog 2019;15(12):e1008115-e1008115.

  6. People also ask
    What does IL-23 do?
    Łukasik Z, Gracey E, Venken K, Ritchlin C, Elewaut D. Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints. Rheumatol (Oxford). (2021) 60:iv16–27. doi: 10.1093/rheumatology/keab385 79.

    Frontiers | IL-23 past, present, and future: a roadmap to advancing IL

    frontiersin.org
    What is the difference between T helper 17 and IL-23?
    T helper 17 (T H 17) cells activated by transforming growth factor-β (TGFβ) and interleukin-6 (IL-6) promote mucosal defence, barrier tissue integrity and curtail immunopathogenic responses, whereas IL-23-activated T H 17 cells promote chronic tissue inflammation during infection, granuloma formation and autoimmunity.

    The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

    nature.com
    Is IL-23 a cytokine?
    IL-23 is an inflammatory cytokine. It has been shown to be a key cytokine for T helper type 17 cell (Th17 cell) maintenance and expansion. Polarisation to a Th17 phenotype is triggered by IL-6 and TGF-β, which activate the Th17 transcription factor RORγt.

    Interleukin 23 - Wikipedia

    en.wikipedia.org
    Is IL-23 a key checkpoint for the induction of autoimmune inflammation?
    Nature 421, 744–748 (2003). This study shows that IL-23 controls a key checkpoint for the induction of autoimmune inflammation. Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715–725 (2000).

    The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

    nature.com
    What role does IL-23 play in inflammation?
    McGeachy, M. J. et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nature Immunol. 10, 314–324 (2009). This paper describes the crucial roles of IL-23 for the in vivo expansion and function of T H 17 cells during inflammation.

    The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

    nature.com
    What is the functional receptor for IL-23?
    The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R. IL-23 was first described by Robert Kastelein and colleagues at the DNAX research institute using a combination of computational, biochemical and cellular immunology approaches. IL-23 is an inflammatory cytokine.

    Interleukin 23 - Wikipedia

    en.wikipedia.org
    Feedback
  7. The Lancet
    https://www.thelancet.com/journals/lancet/article/...

    IL-23 inhibition for chronic inflammatory disease - The Lancet

  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC3277713

    Interleukin-23: as a drug target for autoimmune inflammatory …

  9. Nature
    https://www.nature.com/articles/nri3707

    The IL-23–IL-17 immune axis: from mechanisms to …

    Aug 22, 2014 · IL-23 has crucial roles in the pathogenesis of autoimmunity as it induces a cell population with a unique inflammatory gene signature that includes Il17a (which encodes IL-17A), Il17f, Il6,...

  10. Nature
    https://www.nature.com/articles/nm.3895

    IL-12 and IL-23 cytokines: from discovery to targeted ... - Nature