IRF4 - Wikipedia
Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. [ 5 ] [ 6 ] [ 7 ] IRF4 functions as a key regulatory transcription factor in the development of human immune cells.
IRF4 Gene - GeneCards | IRF4 Protein | IRF4 Antibody
Oct 2, 2024 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple Disease. Among its related pathways are MITF-M-dependent gene expression and Signaling by ALK fusions and activated point mutants.
IRF4 - an overview | ScienceDirect Topics
IRF4. IRF-4 is a transcription factor belonging to the interferon regulatory factor family, primarily expressed in lymphoid cells. It plays a crucial role in the regulation of gene expression in B cells, particularly in enhancing the expression of Ig light chain genes upon B cell activation.
IRF4 interferon regulatory factor 4 [ (human)] - National Center …
Interferon Regulatory Factor 4 (IRF4) Promotes Lipopolysaccharide-Induced Colonic Mucosal Epithelial Cell Proliferation by Regulating Macrophage Polarization. A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Essential role of interferon regulatory factor 4 (IRF4) in immune …
Nov 9, 2016 · Various genetic and functional studies have also pointed to IRF4 as a master regulator for autoimmunity. In this review, the roles of IRF4 in the immune response are briefly summarized and discussed, with particular focus on its essential and distinct functions in immune cell development.
IRFs: master regulators of signalling by Toll-like receptors and ...
Sep 1, 2006 · The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown...
BATF–JUN is critical for IRF4-mediated transcription in T cells
Sep 19, 2012 · The pleiotropic transcription factor IRF4 is shown to regulate CD4+ T-cell differentiation and TH17 function through cooperative binding interactions with BATF and JUN family proteins via AP1 ...
IRF4 and its regulators: evolving insights into the pathogenesis of ...
This review focuses on interferon regulatory factor 4 (IRF4), a member of the IRF family of transcription factors, which has emerged as a crucial controller of both IL-17 and IL-21 production.
Assessing Interferon Regulatory Factor 4 Complex Formation ...
Mar 5, 2024 · Interferon regulatory factor 4 (IRF4) is a crucial transcription factor that plays a vital role in lymphocyte development, including in the fate-determining steps in terminal differentiation. It is also implicated in the development of lymphoid tumors such as multiple myeloma and adult T-cell leukemia. IRF4 can form a homodimer and multiple ...
Transcriptional control of metabolism by interferon regulatory …
May 20, 2024 · This Review discusses the current understanding of IRFs as metabolic regulators, with a particular focus on IRF3 and IRF4.