Hsp27 - Wikipedia
Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene. [5] [6] Hsp27 is a chaperone of the sHsp (small heat shock protein) group among α-crystallin, Hsp20, and others.
Heat shock protein 27 (HSP27): biomarker of disease and …
Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been ...
Heat shock protein 27 (HSP27): biomarker of disease and …
May 7, 2012 · The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.
Hsp27 chaperones FUS phase separation under the modulation …
Mar 30, 2020 · Here, we find that human small heat-shock protein 27 (Hsp27), a canonical chaperone that localizes to stress granules (SGs), prevents FUS from undergoing liquid−liquid phase separation...
Local unfolding of the HSP27 monomer regulates chaperone activity - Nature
Mar 6, 2019 · The small heat-shock protein HSP27 is a redox-sensitive molecular chaperone that is expressed throughout the human body. Here, we describe redox-induced changes to the structure, dynamics, and...
The Role of Hsp27 in Chemotherapy Resistance - PMC
Apr 14, 2022 · Heat shock protein (Hsp)-27 is a small-sized, ATP-independent, chaperone molecule that is overexpressed under conditions of cellular stress such as oxidative stress and heat shock, and protects proteins from unfolding, thus …
The small heat shock protein Hsp27: Present understanding and …
In this review, the structure and functions of Hsp27 and related genes, their role in different cellular processes as well as in stress tolerance, is highlighted.
Hsp27 - an overview | ScienceDirect Topics
Hsp27 is highly expressed in tumor tissues of patients diagnosed with cancer and expression levels correlate with poor prognosis. Hsp27 plays a dual role in cancer and promotes both cancer development by suppressing host anti-cancer response and facilitates the enhanced expression of metastastic genes.
Heat Shock Protein 27: Structure, Function, Cellular Role and ...
Jan 1, 2015 · Hsp27 is an important heat shock protein found in all organisms from prokaryotes to mammals. It is a structurally conserved ATP-independent protein, present in both normal and abnormal tissues. Its expression and induction occur under stressed conditions.
Heat shock protein 27: its potential role in vascular disease
Feb 8, 2006 · Heat shock protein-27 over-expression in various cell types enhances the degradation of ubiquitinated proteins by the 26S proteasome in response to stressful stimuli, such as etoposide or TNF α. Hsp27 binds to polyubiquitin chains and …