CD40 (protein) - Wikipedia
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
CD40 stimulation as a molecular adjuvant for cancer vaccines …
Jul 19, 2021 · In the context of normal responses to pathogens, CD40 stimulation with CD40 ligand (CD154) is either provided by recently activated CD4 + T cells or, in some instances, by natural killer/T...
Molecular basis and therapeutic implications of CD40/CD40L …
The canonical CD40/CD40L signaling is mediated by recruitment of TRAFs and NF-κB activation, which is supplemented by signal pathways such as PI3K/AKT, MAPKs and JAK3/STATs. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling.
Concepts for agonistic targeting of CD40 in immuno-oncology
CD40, expressed by antigen-presenting cells, endothelial cells, and many tumors, plays a fundamental role in connecting innate and adaptive immunity. The multiple investigated strategies to induce CD40 signaling can be broadly grouped …
Cell-specific and divergent roles of the CD40L-CD40 axis in ... - Nature
Jun 18, 2021 · The results of this study show that CD40L plays a divergent, cell type-specific role in atherosclerosis and highlight a crucial role for the CD40L-CD40 T cell-DC axis in atherogenesis.
Bispecific antibodies increase the therapeutic window of CD40 …
Feb 21, 2022 · Therefore, we designed bispecific antibodies that target CD40 activation preferentially to dendritic cells, by coupling the CD40 agonist arm with CD11c-, DEC-205- or CLEC9A-targeting arms.
Molecular mechanism and function of CD40/CD40L engagement in ... - PubMed
CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.
Molecular basis and therapeutic implications of CD40/CD40L …
CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate.
CD40 Agonist Antibodies in Cancer Immunotherapy
CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma.
CD40 is expressed in the subsets of endothelial cells undergoing ...
Dec 18, 2023 · Using EMRECs, we characterized the gene profiles of multiple EndoMT stages and identified CD40 as a novel partial EndoMT-specific marker. CD40 expression was upregulated in the cells undergoing partial EndoMT, but decreased in the full EndoMT cells.