CD33 | ALZFORUM
CD33 in Alzheimer's Disease. Mol Neurobiol. 2013 Aug 28; PubMed. Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013 May 22;78(4):631-43. PubMed.
Clusterin Binds CD33, Souring Microglial Taste for Aβ - ALZFORUM
Apr 19, 2023 · Clusterin binds CD33 dimers, triggering inhibitory signaling. This blocks microglial phagocytosis of Aβ aggregates. What’s more, this cascade is maximally riled if clusterin is complexed with Aβ oligomers while binding CD33. The findings offer an intuitive explanation for how both genes drive AD risk, and support the therapeutic strategy of ...
Antibodies Against Microglial Receptors TREM2 and CD33 Head
May 10, 2019 · Two groups have generated anti-TREM2 antibodies that they claim activate the receptor and stimulate microglia to remove amyloid. One of these has entered a Phase 1 trial. One company is taking an antibody against CD33 into human studies, while another group is investigating an ApoE antibody in mice. Meanwhile, a small molecule that started out ...
CD33 - ALZFORUM
CD33, a transmembrane receptor of the innate immune system, is expressed on the surface of microglial cells. Genome-wide association studies (GWAS) have linked variants in CD33 to Alzheimer’s disease risk, and both disease-promoting and protective alleles have been identified. Uniprot lists three isoforms of human CD33. The 364-amino acid ...
Deleting CD33 Benefits Mice—If Their Microglia Express TREM2
Jul 11, 2019 · Deleting CD33 lowers Aβ burden, but only when TREM2 is expressed. Gene expression changes evoked by CD33 knockout depend on TREM2 expression. Myriad mouse studies implicate TREM2 in microglial recruitment, survival, and in their containment of plaques, while CD33 squelches those processes and riles up pro-inflammatory responses (Griciuc et al ...
AL003 - ALZFORUM
AL003 is a monoclonal antibody that was being co-developed by Alector and Abbvie. According to Alector, it counteracts the function of sialic acid binding immunoglobulin-like lectin 3, aka Siglec-3, an inhibitory microglial transmembrane receptor that reportedly interacts with TREM2 (Oct 2015 news). The gene encoding Siglec-3, CD33, has been ...
Could CD33 Be the Microglial Target for Stimulating Phagocytosis?
Apr 23, 2019 · Also known as Siglec-3, CD33 opposes TREM2 signaling and inhibits phagocytosis ( Aug 2013 news; Griciuc et al., 2013 ). Suppressing CD33 stimulates phagocytosis, slows plaque growth. A protective CD33 mutation could be a gain of function that activates phagocytosis. The CD33 receptor acts as a dimer. At the 14th International Conference on ...
Rubbing Microglia the Right Way? At ADPD, Scientists
Apr 19, 2024 · One was an antibody, discovered in the blood of cognitively sharp centenarians, that blocks the inhibitory receptor CD33, thus freeing microglia to carry out their protective duties with gusto. Other approaches, including an antibody and small molecule, activated TREM2, promoting microglial phagocytosis and plaque clearance.
CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, …
Aug 22, 2013 · CD33 is a sialic acid-binding protein that we recently found to be expressed in microglial cells in the aging human brain ( Griciuc et al., 2013 ). There, it inhibits the clearance of amyloid β, and promotes the deposition of Aβ in plaques, which are major pathological hallmarks of AD. We have previously shown that the CD33 variant, rs3865444 ...
CD33 (clone 24F3) - ALZFORUM
Dec 15, 2022 · Monoclonal antibody 24F3 recognizes human CD33m overexpressed in HEK cells. A) Western blots of lysates of HEK293 cells transfected with myc-tagged human CD33 isoforms or empty vector (mock). Bands representing all three human CD33 isoforms are seen in a blot probed with an anti-myc antibody. CD33-3 and CD33M are seen in a blot probed with ...