BRD2 - Wikipedia
BRD2. Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals [5][6][7]
The BET family in immunity and disease - Nature
Jan 19, 2021 · The bromodomain and extraterminal domain (BET) family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and BRDT) that regulate the expression of many...
BRD2 compartmentalizes the accessible genome - Nature
Apr 11, 2022 · Nature Genetics - BRD2 facilitates mixing and compartmentalization of active chromatin upon cohesin depletion. BRD2’s function is counteracted by cohesin and BRD4.
BRD2 Gene - GeneCards | BRD2 Protein | BRD2 Antibody
Oct 1, 2024 · BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Nut Midline Carcinoma and Adolescence-Adult Electroclinical Syndrome. Among its related pathways are Gene expression (Transcription) and Regulation of activated PAK-2p34 by proteasome mediated degradation.
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional ...
When Brd2 and Brd4 peaks are aligned with the nearest genes, we found that more than 90% of Brd4-associated genes (1,418/1,512) were associated with Brd2 (Figure 1B), suggesting that Brd4 functions jointly with Brd2 to regulate gene transcription.
Bromodomain and extraterminal (BET) proteins: biological ...
Nov 6, 2023 · BRD2, formerly named RING3, is the earliest mammalian BET protein that has been functionally acknowledged. 47 It operates as an atypical protein kinase, mostly localized inside the nucleus. 48,49...
BRD2 Compartmentalizes the Accessible Genome - PMC
Here, we show that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes spatial mixing and compartmentalization of active chromatin after Cohesin loss.
6046 - Gene ResultBRD2 bromodomain containing 2 [ (human)]
Brd2 is a novel protein kinase that plays a role in cell cycle-responsive transcription, recruiting E2F1, TATA Box Binding Protein and histone acetylase activity to E2F-responsive promoters in response to mitogenic stimuli.
BRD2 - an overview | ScienceDirect Topics
BRD2 is considered to be an “epigenetic reader” because its bromodomains binds to acetylated histone protein, thus interpreting the epigenetic landscape and directing its parent transcriptional complexes to specific loci within the genome.
Dissecting the Role of BET Bromodomain Proteins BRD2 ...
Feb 25, 2021 · Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, including direct cytokine secretion, NK cell contact-dependent inflammatory cytokine secretion from monocytes as well as NK cell cytolytic functions.