ATF6 - Wikipedia
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene [5][6][7] and is involved in the unfolded protein response. Function. ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. [8] .
ATF6 as a Nodal Regulator of Proteostasis in the Heart - PMC
(A) In its inactivated state, ATF6 is a 90 kD ER transmembrane protein that is anchored in the membrane by GRP78.(B) Upon ER stress, GRP78 dissociates from the ER luminal domain of ATF6, which allows the 90 kD form of ATF6 to translocate to the Golgi, where is it cleaved by S1P and S2P to liberate the N-terminal approximately 400 amino acids (50 kD) of ATF6 from the …
A lifetime of stress: ATF6 in development and homeostasis
May 25, 2018 · Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors.
ATF6 Gene - GeneCards | ATF6A Protein | ATF6A Antibody
Oct 1, 2024 · ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 and Achromatopsia. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.
The unfolded protein response regulator ATF6 promotes ... - Science
Feb 13, 2018 · Our study uncovers a novel developmental function for ATF6 in guiding human stem cell differentiation, distinct from ER proteostasis regulation in adult somatic cells. We propose that a mechanism by which ATF6 promotes stem cell differentiation is …
Endoplasmic reticulum stress: molecular mechanism and …
Sep 15, 2023 · After the cleavage, ATF6 releases a cytosolic fragment (ATF6f), which directly controls the genes encoding ERAD components such as the basic transcription of leucine zipper (bZip) family and XBP1.
A lifetime of stress: ATF6 in development and homeostasis
Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic ...
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage …
Mar 3, 2017 · ATF6 serves an important role as a previously unappreciated link between the ER stress and oxidative stress gene programs, supporting a novel mechanism by which ATF6 decreases myocardial I/R damage.
The unfolded protein response regulator ATF6 promotes …
Feb 2, 2018 · ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress.
Pharmacologic ATF6 activation confers global protection in …
Jan 14, 2019 · Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases.