CXCR4 - Wikipedia
CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection.
CXCR4 Gene - GeneCards | CXCR4 Protein | CXCR4 Antibody
Oct 1, 2024 — CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome 1 and Macroglobulinemia, Waldenstrom 1. Among its related pathways are Class A/1 (Rhodopsin-like …
Structural insights into CXCR4 modulation and oligomerization
Sep 23, 2024 — We show that CXCR4 adopts distinct subunit conformations in trimeric and tetrameric assemblies, highlighting how oligomerization could allosterically regulate chemokine receptor function.
Frontiers | The Chemokine Receptor CXCR4 in Cell Proliferation …
Aug 27, 2020 — The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of non-hematopoietic cells.
CXCR4, the master regulator of neutrophil trafficking in …
May 7, 2018 — CXCR4 has been shown to be a master regulator of neutrophil retention in the bone marrow and mobilisation during inflammatory responses in mouse at least and unexpectedly also in neutrophil clearance.
CXCR4 C-X-C motif chemokine receptor 4 [ (human)] - National …
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells.
CXCR4, the master regulator of neutrophil trafficking in
In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease.
The Intricate Role of CXCR4 in Cancer - PMC - PubMed Central …
CXCR4, initially discovered for its involvement in HIV entry and leukocytes trafficking, is overexpressed in more than 23 human cancers. Cancer cell CXCR4 overexpression contributes to tumor growth, invasion, angiogenesis, metastasis, relapse, and therapeutic resistance.
CXCR4 gene - MedlinePlus
The CXCR4 gene provides instructions for making a receptor protein that spans the outer membrane of cells, specifically white blood cells and cells in the brain and spinal cord (central nervous system). Learn about this gene and related health conditions.
CXCR4 hyperactivation cooperates with TCL1 in CLL …
Aug 6, 2021 — Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4C1013G) that hyperactivates CXCR4 signaling, we identified CXCR4 as a crucial activator of multiple key oncogenic pathways.